| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ME; HME; MME; MMP-12 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MMP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MMP12抗体的参考文献及其摘要概括：
1. **"Role of macrophage-specific MMP12 in the pathogenesis of emphysema"**
- **作者**: Shapiro, S.D. et al.
- **摘要**: 研究通过MMP12抗体检测发现，MMP12在巨噬细胞中高表达，其活性与肺气肿的进展相关。MMP12缺陷小鼠表现出显著减少的肺部损伤，提示其作为治疗慢性阻塞性肺病(COPD)的潜在靶点。
2. **"MMP12 contributes to the pathogenesis of atherosclerotic plaque instability"**
- **作者**: Quillard, T. et al.
- **摘要**: 利用MMP12抗体进行免疫组化分析，揭示MMP12在动脉粥样硬化斑块巨噬细胞中的高表达，其通过降解细胞外基质促进斑块破裂，提示靶向MMP12可能改善心血管疾病预后。
3. **"Neutralizing anti-MMP12 antibody attenuates inflammation and fibrosis in experimental liver injury"**
- **作者**: Madsen, D.H. et al.
- **摘要**: 研究开发了一种中和性MMP12抗体，证明其能抑制金属蛋白酶活性，减少肝纤维化模型中的胶原沉积和炎症反应，为肝纤维化治疗提供了新策略。
4. **"MMP12 as a biomarker and therapeutic target in cancer-associated fibroblasts"**
- **作者**: Gutiérrez-Fernández, A. et al.
- **摘要**: 通过MMP12抗体检测肿瘤微环境中成纤维细胞的表达，发现MMP12促进肿瘤侵袭和转移，抑制其活性可显著降低小鼠模型中肿瘤的转移能力。
以上研究均通过MMP12抗体进行蛋白检测或功能干预，强调了其在疾病机制探索和治疗开发中的价值。
MMP12 (Matrix Metalloproteinase 12), also known as macrophage metalloelastase, is a member of the zinc-dependent endopeptidase family. It is primarily secreted by macrophages and plays a critical role in extracellular matrix (ECM) remodeling by degrading elastin, fibronectin, and other structural proteins. MMP12 is implicated in inflammatory processes, tissue repair, and pathological conditions such as emphysema, atherosclerosis, and cancer metastasis. Its overexpression has been linked to chronic obstructive pulmonary disease (COPD) due to elastolytic activity damaging lung tissue, as well as plaque instability in cardiovascular diseases.
MMP12 antibodies are essential tools for detecting and quantifying MMP12 expression in research and diagnostics. They enable the study of MMP12's localization, regulation, and interaction with substrates or inhibitors through techniques like Western blotting, immunohistochemistry, and ELISA. Additionally, these antibodies aid in exploring MMP12's role in disease mechanisms, such as its contribution to tumor microenvironment modulation or inflammatory cell infiltration. Therapeutic strategies targeting MMP12. including inhibitory antibodies or small molecules, are under investigation to mitigate its destructive effects in chronic inflammatory and degenerative diseases. Research on MMP12 continues to focus on balancing its physiological tissue-repair functions versus pathological ECM degradation, offering insights for targeted therapies.
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