| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MMP14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MMP14抗体相关的代表性文献的概括性描述(注：文献信息为模拟生成，非真实引用)：
1. **文献名称**：Monoclonal antibody targeting MMP14 inhibits tumor growth and metastasis in preclinical models
**作者**：Sakamoto T, et al.
**摘要**：研究团队开发了一种针对MMP14胞外结构域的单克隆抗体，通过抑制其蛋白水解活性，显著减少小鼠模型中乳腺癌的侵袭和肺转移，提示其治疗潜力。
2. **文献名称**：Characterization of MMP14-specific antibodies for immunohistochemical analysis in human tissues
**作者**：Chen L, et al.
**摘要**：验证了两种商业化MMP14抗体的特异性，对比其在正常/癌变组织中的染色模式，优化了免疫组化实验条件，为临床病理检测提供参考标准。
3. **文献名称**：MMP14 regulates angiogenesis through cleavage of collagen XVIII in a zebrafish model
**作者**：Itoh Y, et al.
**摘要**：利用斑马鱼模型结合MMP14功能阻断抗体，揭示MMP14通过切割XVIII型胶原调控血管生成的分子机制，为抗血管生成治疗提供新靶点。
建议通过PubMed或Web of Science检索关键词"MMP14 antibody"+"specific function/therapeutic application"获取真实文献。
**Background of MMP14 Antibody**
MMP14 (Matrix Metalloproteinase 14), also known as MT1-MMP, is a membrane-anchored protease belonging to the matrix metalloproteinase (MMP) family. It plays a critical role in extracellular matrix (ECM) remodeling by degrading components like collagen, gelatin, and fibronectin, and activating other MMPs (e.g., MMP2). MMP14 is involved in physiological processes such as tissue repair, angiogenesis, and embryogenesis, as well as pathological conditions including cancer metastasis, fibrosis, and inflammatory diseases. Its structure includes a catalytic domain, a hemopexin-like domain, a transmembrane region, and a cytoplasmic tail, enabling cell-surface proteolytic activity and signaling interactions.
MMP14 antibodies are essential tools for detecting the expression, localization, and function of MMP14 in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its role in diseases, particularly in cancer progression where MMP14 overexpression correlates with tumor invasion and poor prognosis. These antibodies may target specific domains (e.g., catalytic or hemopexin regions) and are available as monoclonal or polyclonal forms. Validation using knockout controls or activity assays is crucial to ensure specificity, given the structural similarities among MMPs. Commercial MMP14 antibodies often cite applications in studying ECM dynamics, cell migration, and therapeutic targeting in preclinical models.
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