| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | MTMMP2, SMCP-2, MT2-MMP |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MMP15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP15抗体的3篇参考文献示例(文献信息为模拟概括，具体需根据实际文献调整)：
1. **文献名称**：*MMP15 promotes tumor metastasis through regulation of extracellular matrix remodeling*
**作者**：Smith A, et al.
**摘要**：研究利用MMP15特异性抗体分析其在多种癌细胞系中的表达，发现MMP15通过降解基底膜成分促进肿瘤侵袭，抗体阻断实验证实其功能依赖性。
2. **文献名称**：*Role of MMP15 (MT2-MMP) in collagenolytic activity and angiogenesis*
**作者**：Tanaka M, et al.
**摘要**：通过免疫组化(使用抗MMP15抗体)和基因敲除模型，揭示MMP15在血管内皮细胞中调控胶原降解及病理性血管生成的作用。
3. **文献名称**：*Antibody-based targeting of MMP15 suppresses inflammatory arthritis in murine models*
**作者**：Chen L, et al.
**摘要**：开发了人源化MMP15单克隆抗体，证明其可抑制滑膜成纤维细胞的侵袭性，并在类风湿性关节炎小鼠模型中减轻关节破坏。
如需具体文献，建议通过PubMed或Google Scholar以“MMP15 antibody”或“MT2-MMP antibody”为关键词检索近年研究。
MMP15 (Matrix Metalloproteinase 15), also known as MT2-MMP, is a member of the matrix metalloproteinase family, which plays critical roles in extracellular matrix (ECM) remodeling. This membrane-anchored protease consists of a pro-domain, catalytic domain, hinge region, and hemopexin-like domain. It is activated through proteolytic cleavage of its inhibitory pro-domain and functions in physiological processes like embryonic development, tissue repair, and angiogenesis, as well as pathological conditions including cancer metastasis, inflammation, and fibrosis.
MMP15 is implicated in tumor progression by degrading ECM components (e.g., collagen, fibronectin) and activating other MMPs or growth factors. Its overexpression in cancers (e.g., breast, colorectal) correlates with enhanced invasion, metastasis, and poor prognosis. However, its role may vary depending on tissue context, as it also exhibits tumor-suppressive effects in certain cancers.
MMP15 antibodies are essential tools for detecting protein expression, localization, and activity in research. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study MMP15's involvement in disease mechanisms or therapeutic targeting. Inhibitors targeting MMP15 are under exploration for cancer and inflammatory disorders, though challenges remain in achieving specificity due to structural similarities among MMPs. Research on MMP15 antibodies continues to advance understanding of its dual roles and therapeutic potential.
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