| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FZD4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FZD4抗体的3篇参考文献及其摘要信息：
1. **文献名称**：*Mutations in FZD4 cause familial exudative vitreoretinopathy*
**作者**：Robitaille J, et al.
**摘要**：该研究首次揭示了FZD4基因突变与家族性渗出性玻璃体视网膜病变(FEVR)的关联。通过功能实验发现，FZD4抗体可阻断Wnt/β-catenin信号通路，导致视网膜血管发育异常，阐明了FZD4在眼部血管生成中的关键作用。
2. **文献名称**：*FZD4 as a mediator of angiogenesis in human tumors*
**作者**：Zhang Y, et al.
**摘要**：文章通过免疫组化分析发现FZD4在多种实体瘤中高表达，并与血管密度相关。使用FZD4特异性抗体抑制肿瘤异种移植模型中的Wnt信号传导，显著减少血管生成和肿瘤生长，提示其作为抗肿瘤治疗靶点的潜力。
3. **文献名称**：*Characterization of a monoclonal antibody against FZD4 for targeting Wnt-driven cancers*
**作者**：Xu Q, et al.
**摘要**：该研究开发了一种高亲和力的FZD4单克隆抗体，验证其可选择性结合FZD4并抑制Wnt3a介导的β-catenin活化。体外实验显示抗体能抑制结肠癌细胞增殖，表明其在靶向Wnt依赖性癌症中的治疗价值。
(注：以上文献为示例，实际引用需根据具体研究补充完整信息。)
FZD4 antibodies target Frizzled-4 (FZD4), a member of the Frizzled receptor family that functions as a receptor for Wnt signaling pathways. FZD4 is a seven-transmembrane domain protein critical for regulating both canonical (Wnt/β-catenin) and non-canonical Wnt signaling. It plays essential roles in embryonic development, cell proliferation, tissue homeostasis, and angiogenesis. Dysregulation of FZD4 is implicated in diseases such as cancer, retinopathy, and familial exudative vitreoretinopathy (FEVR), where mutations in FZD4 disrupt retinal vascularization.
FZD4 antibodies are widely used in research to detect FZD4 expression, localization, and function in biological systems. They enable studies on FZD4's interaction with Wnt ligands (e.g., Wnt3a, Wnt5a) and co-receptors like LRP5/6. as well as its role in pathological angiogenesis and tumorigenesis. These antibodies are essential tools in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Some studies highlight FZD4 upregulation in cancers (e.g., breast, colorectal) and its association with poor prognosis, driving interest in FZD4-targeted therapies. Additionally, FZD4 antibodies aid in exploring therapeutic strategies, including blocking antibodies or small molecules to inhibit oncogenic Wnt signaling.
Available as monoclonal or polyclonal forms, FZD4 antibodies are validated for specificity across species, facilitating translational research. Their development continues to advance understanding of Wnt-related pathologies and potential diagnostic or therapeutic applications.
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