| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TIL4; CD282 |
| WB Predicted band size | 90 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TLR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TLR2抗体的示例参考文献(注：以下为虚构示例，实际文献请通过学术数据库查询)：
1. **文献名称**：*TLR2-specific antibodies block inflammatory responses in sepsis models*
**作者**：Smith A, et al.
**摘要**：研究证明，针对TLR2的单克隆抗体可通过抑制病原体相关分子模式(如脂蛋白)的结合，显著降低脓毒症模型小鼠的全身炎症反应和器官损伤。
2. **文献名称**：*Structural basis of TLR2 activation by bacterial ligands and therapeutic antibodies*
**作者**：Zhang L, et al.
**摘要**：通过冷冻电镜解析TLR2与抗体复合物的结构，揭示抗体通过竞争性结合TLR2的配体识别区域，阻断下游NF-κB信号通路的分子机制。
3. **文献名称**：*Anti-TLR2 antibody enhances bacterial clearance in chronic wound infections*
**作者**：Wang Y, et al.
**摘要**：在糖尿病小鼠伤口感染模型中，TLR2中和抗体通过调节巨噬细胞极化，促进金黄色葡萄球菌的清除并加速伤口愈合，提示其治疗慢性感染的潜力。
4. **文献名称**：*Dual role of TLR2 antibodies in autoimmune disease modulation*
**作者**：Kumar R, et al.
**摘要**：研究发现不同表位特异性的TLR2抗体在类风湿性关节炎模型中具有双向调节作用，部分抗体抑制炎症，而另一些可能通过受体交联加剧疾病进展。
**提示**：实际文献需通过PubMed、Web of Science等平台检索，建议结合关键词“TLR2 antibody”“therapeutic”“mechanism”筛选近年高被引研究。
Toll-like receptor 2 (TLR2) is a key pattern recognition receptor in the innate immune system, responsible for detecting conserved microbial components such as bacterial lipoproteins, peptidoglycan, and lipoteichoic acid. TLR2 antibodies are essential tools for studying its expression, function, and signaling pathways. These antibodies are widely used in research to visualize TLR2 localization via immunohistochemistry, measure protein levels through Western blotting, or analyze surface expression on immune cells (e.g., monocytes, macrophages) using flow cytometry.
TLR2 plays a critical role in host defense against pathogens but is also implicated in chronic inflammatory diseases (e.g., atherosclerosis, sepsis) and autoimmune disorders when dysregulated. Antibodies targeting TLR2 help elucidate its interactions with ligands, downstream adaptor proteins (e.g., MyD88), and cross-talk with other TLRs or receptors. Neutralizing TLR2 antibodies can block pro-inflammatory cytokine production (e.g., TNF-α, IL-6), offering insights into therapeutic strategies for inflammation-driven conditions.
Commercial TLR2 antibodies are typically raised in hosts like rabbits or mice, with clones validated for specificity in human, mouse, or rat samples. Challenges include ensuring minimal cross-reactivity with other TLRs (e.g., TLR1. TLR6) due to structural similarities. Recent applications extend to studying TLR2's role in cancer immunotherapy, microbiome interactions, and vaccine adjuvant development, underscoring its broad biomedical relevance.
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