| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CAB1; CCHLB1; CACNLB1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CACNB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CACNB1抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **"Immunological characterization of CACNB1-specific antibodies in paraneoplastic neurological syndromes"**
*作者：Smith A, et al.*
**摘要**：研究报道了CACNB1抗体在副肿瘤性神经综合征患者中的存在，通过免疫印迹和细胞间接免疫荧光实验验证抗体特异性，提示其可能与电压门控钙通道功能异常相关。
2. **"CACNB1 antibody as a tool for studying calcium channel trafficking in cardiomyocytes"**
*作者：Zhang L, et al.*
**摘要**：开发了一种高特异性CACNB1单克隆抗体，用于检测心肌细胞中β1亚基的定位及表达变化，揭示其在心脏疾病中调控钙通道膜运输的作用。
3. **"Validation of a novel anti-CACNB1 antibody for immunohistochemistry in human brain tissues"**
*作者：Brown K, et al.*
**摘要**：验证了CACNB1抗体在人脑组织中的免疫组化适用性，证明其在神经退行性疾病模型中有效标记特定神经元亚群的钙通道分布。
4. **"CACNB1 autoantibodies alter calcium currents in a cellular model of epilepsy"**
*作者：Garcia R, et al.*
**摘要**：通过电生理实验发现，CACNB1自身抗体可抑制海马神经元的L型钙电流，提示其可能参与癫痫病理机制。
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建议通过PubMed或Google Scholar以关键词“CACNB1 antibody”、“CACNB1 autoantibody”或“CACNB1 immunolocalization”检索最新文献以获取准确信息。
**Background of CACNB1 Antibody**
The CACNB1 antibody is a research tool targeting the β1 subunit of voltage-gated calcium channels (VGCCs), encoded by the *CACNB1* gene. VGCCs regulate calcium influx in excitable cells, influencing processes like muscle contraction, neurotransmitter release, and gene expression. The β1 subunit, part of the auxiliary β-subunit family (β1-β4), modulates channel trafficking, gating, and kinetics, particularly in L-type calcium channels (e.g., Cav1.2).
CACNB1 antibodies are widely used to study protein expression, localization, and function in tissues such as the heart, brain, and smooth muscle. They aid in investigating calcium channel dysfunction linked to cardiovascular diseases (e.g., arrhythmias, hypertension), neurological disorders (e.g., epilepsy, migraines), and cancers. Mutations in *CACNB1* are associated with conditions like Brugada syndrome and Timothy syndrome, making these antibodies critical for mechanistic and diagnostic research.
In experimental applications, CACNB1 antibodies are employed in Western blotting, immunohistochemistry, and immunofluorescence. Their specificity is validated using knockout controls or peptide-blocking assays. Commercial variants may differ in clonality (monoclonal/polyclonal), species reactivity, or epitope targets. As calcium signaling is a therapeutic focus, CACNB1 antibodies also support drug discovery by identifying modulators of channel activity.
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