| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CALB |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CALB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CALB1抗体的3篇参考文献示例(内容基于公开研究整理，非真实文献，仅供参考)：
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1. **标题**：Calbindin D-28k (CALB1) Expression in Human Neurodegenerative Disorders
**作者**：Schwaller B, et al.
**年份**：2003
**摘要**：研究通过CALB1抗体检测人脑组织中CALB1的表达，发现其在阿尔茨海默病和帕金森病患者中显著减少，提示其与神经元钙稳态失衡及退行性病变相关。
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2. **标题**：CALB1 as a Marker for Gastrointestinal Cancer Progression
**作者**：Kim S, et al.
**年份**：2015
**摘要**：利用CALB1抗体分析胃癌和结直肠癌组织，发现CALB1低表达与肿瘤侵袭性及患者预后不良相关，可能作为潜在的生物标志物。
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3. **标题**：Comparative Evaluation of CALB1 Antibodies in Immunohistochemistry
**作者**：Porter AG, et al.
**年份**：2019
**摘要**：对比不同商业来源的CALB1抗体在小鼠和人类脑组织中的特异性与灵敏度，为实验中选择可靠抗体提供依据，强调部分抗体存在交叉反应问题。
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(注：以上文献信息为示例，实际引用需以真实发表的论文为准。)
CALB1 (Calbindin-D28k) is a calcium-binding protein belonging to the EF-hand superfamily, widely recognized for its role in regulating intracellular calcium homeostasis. Expressed predominantly in the central nervous system (CNS), including the hippocampus, cerebellum, and cortex, CALB1 buffers calcium ions, modulates neuronal excitability, and protects against calcium-induced cytotoxicity. It is also found in non-neural tissues like kidney, pancreas, and endocrine cells, where it participates in calcium signaling and cellular differentiation.
CALB1 antibodies are essential tools in neuroscience and biomedical research, enabling the detection and localization of CALB1 in tissues and cells via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. These antibodies help identify CALB1-expressing neuronal subpopulations, such as Purkinje cells in the cerebellum or specific interneurons in the hippocampus, aiding studies on neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), epilepsy, and neurodevelopmental disorders linked to calcium dysregulation.
Additionally, CALB1 antibodies are used in cancer research, as altered CALB1 expression is observed in tumors like neuroblastomas and colorectal cancers. Validated for specificity across human, mouse, and rat models, these antibodies support both basic research and clinical diagnostics. Their utility extends to developmental biology, where CALB1 expression patterns help map neuronal maturation and circuit formation. Reliable CALB1 detection remains critical for understanding calcium-mediated cellular processes and disease mechanisms.
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