首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CAPZA3 Antibody

  • 中文名: CAPZA3抗体
  • 别    名: Gsg3; CAPPA3
货号: IPDX08100
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesGsg3; CAPPA3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CAPZA3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于CAPZA3抗体的模拟参考文献示例(请注意文献信息为虚构,建议通过学术数据库核实真实文献):

---

1. **文献名称**: "CAPZA3 is essential for spermatogenesis in mice: Characterization of a testis-specific actin-capping protein"

**作者**: Zhang, Y., et al.

**摘要**: 本研究利用特异性CAPZA3抗体,发现该蛋白在小鼠睾丸生精细胞中高表达,尤其在精子形成阶段。基因敲除实验表明CAPZA3缺失导致精子形态异常和不育,提示其在F-actin动态调控中的关键作用。

2. **文献名称**: "Development of a polyclonal antibody against human CAPZA3 and its application in male infertility studies"

**作者**: Chen, L., et al.

**摘要**: 研究团队开发了人源CAPZA3多克隆抗体,并通过Western blot和免疫组化验证其特异性。该抗体用于分析不育患者睾丸活检样本,发现CAPZA3表达水平降低与精子发生障碍显著相关。

3. **文献名称**: "CAPZA3 as a potential biomarker for testicular germ cell tumors: Immunohistochemical analysis using a novel monoclonal antibody"

**作者**: Li, X., et al.

**摘要**: 通过构建CAPZA3单克隆抗体,研究者发现其在睾丸生殖细胞肿瘤中异常高表达。抗体特异性经流式细胞术验证,提示CAPZA3可能作为诊断标记物或治疗靶点。

4. **文献名称**: "Dynamic localization of CAPZA3 during acrosome formation revealed by antibody-based imaging"

**作者**: García-Robledo, J.E., et al.

**摘要**: 利用免疫荧光和CAPZA3特异性抗体,研究揭示了该蛋白在精子顶体形成过程中的时空分布变化,表明其与actin重塑密切关联,为生殖细胞发育机制提供新见解。

---

建议通过**PubMed**或**Web of Science**搜索真实文献,关键词:CAPZA3 antibody, spermatogenesis, actin capping。

背景信息

The CAPZA3 antibody is designed to target the CAPZA3 protein, a member of the F-actin capping protein alpha subunit family. CAPZA3. specifically expressed in the testis and germ cells, plays a critical role in regulating actin cytoskeleton dynamics during spermatogenesis. Unlike its ubiquitously expressed homologs (CAPZA1 and CAPZA2), CAPZA3 exhibits tissue-specific expression, suggesting specialized functions in sperm development, particularly in acrosome formation and sperm head shaping. Studies indicate that CAPZA3 interacts with its beta subunit (CAPZB) to stabilize actin filaments, ensuring structural integrity during spermiogenesis. Dysregulation of CAPZA3 has been linked to male infertility, as mutations or altered expression may disrupt sperm maturation or motility. The CAPZA3 antibody is widely used in reproductive biology research to investigate protein localization, expression levels, and molecular mechanisms underlying fertility issues. It enables techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of testicular pathologies or genetic models. Commercial antibodies are typically validated for specificity in human or mouse tissues, supporting both basic and clinical research focused on understanding cytoskeletal contributions to gametogenesis and reproductive health.

客户数据及评论

折叠内容

大包装询价

×