Rabbit Polyclonal CASQ2 Antibody

CASQ2 (calsequestrin-2) is a calcium-binding protein predominantly expressed in the sarcoplasmic reticulum (SR) of cardiac myocytes, where it plays a critical role in buffering Ca²⁺ ions and regulating excitation-contraction coupling. Mutations in the CASQ2 gene are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare inherited arrhythmia disorder characterized by stress-induced ventricular tachycardia and sudden cardiac death. CASQ2 antibodies are essential tools for studying the expression, localization, and functional alterations of CASQ2 in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess CASQ2 protein levels in cardiac tissues, cellular models, or genetically engineered animals. Research utilizing CASQ2 antibodies has elucidated its role in maintaining calcium homeostasis, particularly in how loss-of-function mutations disrupt SR calcium storage, leading to aberrant calcium release and arrhythmogenesis. Additionally, CASQ2 antibodies aid in diagnosing CPVT and differentiating it from other calcium-handling disorders. Recent studies also explore CASQ2's interaction with other SR proteins, such as junctin and triadin, to form the calsequestrin complex, which stabilizes calcium dynamics. The development of specific, high-affinity CASQ2 antibodies continues to advance mechanistic insights into cardiac arrhythmias and potential therapeutic strategies targeting calcium dysregulation.