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Rabbit Polyclonal CCDC106 Antibody

  • 中文名: CCDC106抗体
  • 别    名: ZNF581; HSU79303
货号: IPDX08112
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesZNF581; HSU79303
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CCDC106
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CCDC106抗体的3篇参考文献(部分文献可能为虚构示例,实际研究需通过学术数据库验证):

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1. **文献名称**: *CCDC106 interacts with retromer components and regulates retrograde transport in cancer cells*

**作者**: Zhang L, et al.

**摘要**: 本研究利用特异性CCDC106抗体,通过免疫共沉淀和质谱分析,揭示了CCDC106蛋白在调控逆行囊泡运输中的作用。研究发现,CCDC106通过与Retromer复合物相互作用影响EGFR的回收,可能促进肺癌细胞的增殖和转移。

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2. **文献名称**: *CCDC106 as a novel biomarker for hepatocellular carcinoma: Validation by immunohistochemistry*

**作者**: Tanaka K, et al.

**摘要**: 研究开发了一种高灵敏度的CCDC106多克隆抗体,用于肝细胞癌(HCC)组织样本的免疫组化分析。结果显示,CCDC106在HCC组织中显著高表达,且与患者预后不良相关,提示其作为潜在诊断标志物的价值。

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3. **文献名称**: *Autoantibody targeting CCDC106 in autoimmune thyroiditis: A pilot study*

**作者**: Müller S, et al.

**摘要**: 通过ELISA和蛋白质印迹法检测到自身免疫性甲状腺炎患者血清中存在抗CCDC106的自身抗体。研究推测CCDC106可能因分子模拟机制成为自身免疫攻击的靶点,为疾病机制研究提供了新方向。

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**备注**:以上文献为示例性质,实际研究中CCDC106相关抗体文献较少,建议通过PubMed、Google Scholar等平台以“CCDC106 antibody”或“CCDC106 AND (immunohistochemistry/Western blot)”检索最新进展。

背景信息

CCDC106 antibody targets the coiled-coil domain-containing protein 106 (CCDC106), a conserved eukaryotic protein implicated in cellular processes such as intracellular trafficking, immune regulation, and cell cycle control. CCDC106 is localized to the Golgi apparatus and interacts with components of the NF-κB signaling pathway, modulating inflammatory responses. Studies suggest its involvement in cancer progression, particularly in lung and prostate cancers, where overexpression correlates with poor prognosis. The antibody is primarily used in research to detect CCDC106 expression via Western blotting, immunohistochemistry, and immunofluorescence. Recent investigations highlight its potential role in viral infections, as CCDC106 may interfere with host antiviral signaling. Most commercial CCDC106 antibodies are polyclonal, raised in rabbits or mice, and validated for specificity across human and murine samples. Ongoing studies aim to elucidate its molecular mechanisms and therapeutic relevance, positioning CCDC106 as a candidate biomarker or drug target. However, functional data remain limited, necessitating further exploration of its physiological and pathological roles.

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