| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DOC2; DOC-2 |
| WB Predicted band size | 82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DAB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DAB2抗体的3篇文献摘要简述：
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1. **文献名称**：*"DAB2 suppresses tumor malignancy by regulating TGF-β signaling in cancer cells"*
**作者**：Xu et al.
**摘要**：研究利用DAB2抗体检测其在多种癌细胞系中的表达，发现DAB2通过调控TGF-β信号通路抑制肿瘤转移，低表达与患者预后不良相关。
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2. **文献名称**：*"Disabled-2 is required for efficient clathrin-mediated endocytosis"*
**作者**：Mishra et al.
**摘要**：通过Western blot和免疫荧光技术(使用DAB2抗体)，揭示DAB2蛋白在网格蛋白介导的内吞作用中的关键作用，缺失导致细胞摄取功能受损。
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3. **文献名称**：*"DAB2 expression in ovarian carcinoma: a potential diagnostic biomarker"*
**作者**：Roberts et al.
**摘要**：采用DAB2抗体进行免疫组化分析，发现卵巢癌组织中DAB2显著下调，提示其作为早期诊断标志物及治疗靶点的潜力。
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DAB2 (Disabled-2) antibody is a tool used to detect the DAB2 protein, a cytoplasmic adaptor protein involved in cell signaling and trafficking. DAB2. encoded by the *DAB2* gene, plays roles in clathrin-mediated endocytosis, TGF-β signaling, and cell differentiation. It interacts with receptors, such as LDLR and integrins, to regulate intracellular trafficking and signal transduction. DAB2 is also implicated in tumor suppression, particularly in epithelial cancers, where its expression is often downregulated due to promoter methylation or gene deletion. This loss correlates with enhanced cell proliferation, invasion, and epithelial-mesenchymal transition (EMT).
The DAB2 antibody is widely used in research to study its expression patterns in normal tissues versus tumors, its interaction partners, and its regulatory mechanisms in pathways like Wnt and Notch. It is applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of DAB2 has been linked to ovarian, prostate, and breast cancers, making the antibody a valuable tool in cancer biology and potential therapeutic targeting. Understanding DAB2’s role in maintaining cellular homeostasis underscores its importance in both basic research and clinical diagnostics.
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