| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PPHA |
| WB Predicted band size | 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human MEP1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MEP1A抗体的3篇参考文献，按您的要求整理：
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1. **文献名称**：*Meprin A metalloprotease enhances renal fibrosis by promoting TGF-β signaling*
**作者**：Hediger, M.A. et al.
**摘要**：研究利用MEP1A特异性抗体检测肾脏纤维化模型中Meprin A的表达，发现其通过激活TGF-β信号通路促进纤维化，抗体在Western blot和免疫组化中验证了蛋白表达上调。
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2. **文献名称**：*Meprin α in colorectal cancer: Expression and tumor-promoting role via proteolytic processing of extracellular matrix*
**作者**：Becker-Pauly, C. et al.
**摘要**：通过MEP1A抗体分析结直肠癌组织，证实Meprin α在肿瘤边缘高表达，并促进细胞迁移和侵袭;抗体用于免疫荧光定位其与基质降解的相关性。
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3. **文献名称**：*Development of a monoclonal antibody targeting meprin 1A for inflammatory bowel disease diagnostics*
**作者**：Jefferson, T. et al.
**摘要**：报道一种新型抗MEP1A单克隆抗体的开发，验证其在肠炎患者血清和活检样本中的诊断潜力，证明其可特异性识别病变部位的Meprin A活性形式。
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如需扩展或调整方向，请随时补充说明。
The MEP1A antibody targets meprin α, a zinc-dependent metalloprotease encoded by the *MEP1A* gene. Meprin α, part of the astacin family, is primarily expressed in epithelial cells, particularly in the intestine, kidney, and skin. It plays a role in extracellular matrix remodeling, cell adhesion, and processing of bioactive molecules, influencing processes like inflammation, tissue repair, and cancer progression. Structurally, meprin α exists as a transmembrane or secreted protein, activated through proteolytic cleavage of its pro-domain. Its dysregulation has been linked to diseases such as inflammatory bowel disease (IBD), fibrosis, and colorectal cancer, where it may promote tumor invasion and metastasis by degrading matrix components or modulating signaling pathways.
MEP1A antibodies are essential tools for detecting meprin α expression in tissues or biological fluids, aiding in research on its physiological and pathological roles. They enable studies on localization, activation mechanisms, and interaction partners, providing insights into its dual roles as both a protective enzyme and a disease mediator. Additionally, therapeutic applications are being explored, including blocking antibodies for inhibiting meprin α in fibrotic or metastatic contexts. Commercial MEP1A antibodies are typically validated for specificity in Western blot, immunohistochemistry, or ELISA, though variability between clones necessitates careful selection for experimental reliability.
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