Rabbit Polyclonal MEI1 Antibody

The MEI1 (Meiotic Inefficient 1) antibody is a research tool used to study the MEI1 protein, encoded by the *MEI1* gene, which plays a critical role in mammalian meiosis. MEI1 is essential for proper chromosome segregation during gametogenesis, particularly in homologous recombination, synapsis, and the suppression of non-specific DNA interactions. Its dysfunction is linked to infertility, meiotic arrest, or chromosomal abnormalities in model organisms like mice. The MEI1 antibody enables detection and localization of the protein in tissues or cell cultures, aiding investigations into reproductive biology, germ cell development, and disorders like premature ovarian failure or azoospermia. Researchers employ it in techniques such as Western blotting, immunohistochemistry, or immunofluorescence to assess MEI1 expression patterns under experimental conditions, including gene knockout studies or exposure to meiotic disruptors. Commercially available antibodies are typically validated for specificity and sensitivity, though cross-reactivity or batch variability may require optimization. Understanding MEI1's role through such tools contributes to broader insights into fertility mechanisms, contraceptive development, and genetic causes of reproductive disorders.