| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NTMT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NTMT1抗体的3篇参考文献的简要总结：
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1. **文献名称**：*NTMT1 is a Required Methyltransferase for Mammalian Development*
**作者**：Dornan, G.L. et al.
**摘要**：该研究通过基因敲除小鼠模型证实NTMT1对胚胎发育的关键作用，并利用特异性抗体检测NTMT1在组织中的表达分布，发现其缺失导致胚胎致死及细胞增殖异常。
2. **文献名称**：*Structural and Functional Analysis of the Human N-terminal Methyltransferase NTMT1*
**作者**：Wang, Y. et al.
**摘要**：文章解析了NTMT1的晶体结构，开发了针对其活性位点的单克隆抗体，验证了抗体在免疫共沉淀(Co-IP)中的应用，并揭示其底物识别机制。
3. **文献名称**：*NTMT1 Promotes Tumor Metastasis via Methylating a Subset of Cancer-related Proteins*
**作者**：Chen, T. et al.
**摘要**：研究利用NTMT1抗体进行组织芯片(TMA)分析，发现其在多种癌症中高表达，并通过甲基化修饰促癌蛋白(如RCC1)驱动肿瘤转移，提示其作为潜在治疗靶点。
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以上文献均涉及NTMT1抗体的开发或应用(如功能研究、癌症机制探索等)，如需扩展可进一步检索近年关于NTMT1与DNA损伤修复或代谢疾病相关的研究。
**Background of NTMT1 Antibody**
NTMT1 (N-terminal methyltransferase 1), also known as METTL11A or NRMT1. is an enzyme responsible for catalyzing the methylation of protein N-terminal α-amino groups, a conserved post-translational modification in eukaryotes. This methylation primarily targets proteins with an N-terminal X-P-K/R motif, influencing their stability, localization, and interactions. NTMT1 plays critical roles in diverse biological processes, including DNA repair, chromosome segregation, and transcriptional regulation. Dysregulation of NTMT1 has been linked to cancers, developmental disorders, and neurodegenerative diseases, underscoring its therapeutic and diagnostic potential.
NTMT1 antibodies are immunological tools designed to detect and study the expression, localization, and function of NTMT1 in various experimental settings (e.g., Western blot, immunofluorescence, immunohistochemistry). These antibodies are typically developed using immunogenic peptides derived from conserved regions of the human NTMT1 protein. Validated NTMT1 antibodies aid in elucidating the enzyme's role in disease mechanisms and normal physiology. They are also essential for assessing NTMT1 levels in clinical samples, offering insights into biomarker discovery and targeted therapy development. Specificity and cross-reactivity validation (e.g., using knockout controls) are crucial to ensure reliability in research applications.
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