| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NYD-sp9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MFAP3L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **MFAP3L抗体** 的模拟参考文献示例(基于公开研究主题归纳，非真实文献)：
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1. **文献名称**：*MFAP3L as a novel biomarker in hepatocellular carcinoma: Antibody-based detection and prognostic significance*
**作者**：Li X, et al.
**摘要**：该研究通过开发高特异性MFAP3L多克隆抗体，利用免疫组化技术分析肝癌组织样本，发现MFAP3L高表达与患者不良预后显著相关，提示其可作为潜在治疗靶点。
2. **文献名称**：*MFAP3L regulates extracellular matrix remodeling in vascular development: Insights from antibody-mediated knockdown models*
**作者**：Smith J, et al.
**摘要**：研究采用MFAP3L抗体进行免疫荧光和Western blot分析，揭示MFAP3L通过调控弹性纤维组装影响血管发育，为心血管疾病机制提供新见解。
3. **文献名称**：*Development and validation of a monoclonal MFAP3L antibody for diagnostic applications in ovarian cancer*
**作者**：Wang Y, et al.
**摘要**：文章报道了一种新型MFAP3L单克隆抗体的制备与验证，通过ELISA和免疫组化证实其在卵巢癌早期诊断和分期中的临床应用潜力。
4. **文献名称**：*MFAP3L antibody reveals its role in cell-matrix adhesion and migration in triple-negative breast cancer*
**作者**：Chen R, et al.
**摘要**：利用MFAP3L抗体阻断实验，证明MFAP3L通过整合素信号通路促进乳腺癌细胞迁移，为靶向治疗提供实验依据。
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注：以上为基于领域知识的模拟文献，实际研究中请通过PubMed或Google Scholar以“MFAP3L antibody”为关键词检索最新论文。
The MFAP3L (Microfibril-Associated Protein 3-Like) antibody is a tool used to study the MFAP3L protein, a member of the microfibril-associated glycoprotein (MAGP) family. MFAP3L is encoded by the *MFAP3L* gene located on human chromosome 4q32.1 and shares structural homology with other microfibril-associated proteins involved in extracellular matrix (ECM) organization. The protein is implicated in regulating microfibril assembly, which contributes to the structural integrity of elastic fibers and connective tissues. While its exact biological functions remain under investigation, MFAP3L is thought to interact with fibrillin-rich microfibrils, influencing cell adhesion, tissue development, and ECM remodeling processes.
Research using MFAP3L antibodies has highlighted its potential roles in pathological conditions. Studies suggest associations with cardiovascular diseases, fibrotic disorders, and cancer progression, where ECM dysregulation is a hallmark. For instance, altered MFAP3L expression has been observed in certain tumors, possibly affecting tumor microenvironment interactions. The antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize MFAP3L in tissues or assess its expression levels. Commercial availability of MFAP3L antibodies has facilitated exploratory studies, though challenges persist in fully elucidating its mechanistic pathways and validating specificity across experimental models. Ongoing research aims to clarify its physiological significance and therapeutic potential in ECM-related diseases.
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