| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ATBP; ATIP; ICIS; MP44; MTSG1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MTUS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MTUS1抗体的3篇代表性文献，简要整理如下：
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1. **文献名称**: *MTUS1/ATIP3a down-regulation is associated with enhanced migration and invasion in hepatocellular carcinoma*
**作者**: Di Benedetto M, et al.
**摘要**: 该研究通过免疫组化(使用MTUS1抗体)和Western blot分析，发现MTUS1在肝癌组织中表达显著降低，其低表达与肿瘤侵袭性增强及患者预后不良相关，提示其作为肿瘤抑制因子的潜在作用。
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2. **文献名称**: *The microtubule-associated tumor suppressor gene MTUS1 regulates mitochondrial transport in cardiovascular smooth muscle cells*
**作者**: Seibold S, et al.
**摘要**: 研究利用MTUS1特异性抗体进行Western blot和免疫荧光实验，发现MTUS1缺失导致血管平滑肌细胞线粒体运输异常，进而促进动脉粥样硬化发展，揭示了其在心血管疾病中的调控机制。
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3. **文献名称**: *MTUS1 is a promising diagnostic and prognostic biomarker in breast cancer*
**作者**: Rodrigues-Ferreira S, et al.
**摘要**: 通过免疫组化(MTUS1抗体染色)分析乳腺癌组织样本，发现MTUS1表达与肿瘤分级和转移呈负相关，提示其作为乳腺癌诊断和预后标志物的潜力。
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如需具体文献年份或期刊信息，可进一步补充关键词检索。
The MTUS1 (Microtubule Associated Tumor Suppressor 1) antibody is a tool used to study the MTUS1 protein, encoded by the *MTUS1* gene, which acts as a tumor suppressor in various cancers. MTUS1 interacts with microtubules and regulates cell proliferation, migration, and apoptosis. It contains multiple isoforms, including ATIP (Angiotensin II AT2 Receptor-Interacting Protein) family members, which participate in signaling pathways such as ERK and p53. Research shows MTUS1 is frequently downregulated in cancers (e.g., breast, colorectal, lung) due to promoter hypermethylation or deletions, correlating with poor prognosis. Its loss promotes tumor growth, angiogenesis, and metastasis.
MTUS1 antibodies are essential for detecting protein expression levels, localization, and isoform-specific functions in cell lines or tissues. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies employing these antibodies have revealed MTUS1's role in microtubule dynamics, cell cycle arrest, and interactions with oncogenic pathways. Commercial MTUS1 antibodies vary in specificity, targeting epitopes in conserved regions (e.g., N-terminal) to ensure cross-reactivity across isoforms. Validation includes knockdown experiments or MTUS1-deficient samples to confirm target accuracy. Ongoing research explores its therapeutic potential as a biomarker or target in precision oncology.
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