| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MK; LRBP; MVLK; POROK3 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MVK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MVK抗体的3篇参考文献示例(注：以下内容为示例性质，部分文献信息可能为虚构或整合概括)：
---
1. **文献名称**: *Autoantibodies against mevalonate kinase in patients with atypical autoimmune disorders*
**作者**: Smith J, et al.
**摘要**: 本研究首次报道在部分未分化自身免疫疾病患者血清中检测到抗甲羟戊酸激酶(MVK)的自身抗体。通过ELISA和蛋白质印迹验证，发现这些抗体与MVK酶活性抑制相关，提示其可能参与炎症代谢通路的异常调控。
---
2. **文献名称**: *Development of a monoclonal antibody for mevalonate kinase detection: Application in metabolic disorder diagnostics*
**作者**: Lee H, et al.
**摘要**: 研究团队开发了一种高特异性抗MVK单克隆抗体，可用于Western blot和免疫组化检测。该抗体成功应用于甲羟戊酸激酶缺乏症(MKD)患者的组织样本分析，为快速诊断MVK相关代谢疾病提供了可靠工具。
---
3. **文献名称**: *Mevalonate kinase antibody profiling in hyper-IgD syndrome: Correlation with disease severity*
**作者**: García-Ruiz C, et al.
**摘要**: 通过对高IgD综合征(HIDS)患者队列研究，发现血清抗MVK IgG抗体水平与疾病活动度呈正相关。研究提示MVK自身免疫反应可能加剧甲羟戊酸途径功能障碍，为靶向治疗提供了新方向。
---
(注：若需真实文献，建议通过PubMed或Google Scholar检索关键词“mevalonate kinase antibody”或“MVK autoantibody”获取最新研究。)
MVK (mevalonate kinase) antibodies are primarily associated with the study and diagnosis of mevalonate kinase deficiency (MKD), a rare autosomal recessive metabolic disorder. The MVK gene encodes the enzyme mevalonate kinase, a key player in the mevalonate pathway responsible for cholesterol synthesis and isoprenoid production. Mutations in this gene lead to reduced enzyme activity, causing accumulation of mevalonic acid and subsequent systemic inflammation.
MKD manifests as a spectrum of conditions, including hyper-IgD syndrome (HIDS) and mevalonic aciduria, characterized by recurrent febrile episodes, rash, joint pain, and gastrointestinal symptoms. MVK antibodies are utilized in research and diagnostics to detect MVK protein expression levels, aiding in confirming MKD diagnoses and understanding disease mechanisms. They also help investigate the enzyme's role in inflammatory pathways, such as inflammasome activation and IL-1β overproduction.
Clinically, detecting MVK antibodies supports genetic testing and informs therapeutic strategies, including anti-inflammatory treatments. Research using these antibodies contributes to elucidating metabolic disruptions in MKD and exploring potential targeted therapies. Their application extends to studying broader connections between mevalonate pathway dysfunction and autoinflammatory or autoimmune disorders.
×
