Rabbit Polyclonal NDUFS5 Antibody

The NDUFS5 antibody is a crucial tool for studying the NDUFS5 protein, a key subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) in the electron transport chain. Complex I catalyzes NADH oxidation and ubiquinone reduction, coupling electron transfer to proton pumping for ATP synthesis. NDUFS5. located in the iron-sulfur cluster-containing module of Complex I, contributes to structural stability and enzymatic activity. Mutations or deficiencies in NDUFS5 are linked to mitochondrial disorders, such as Leigh syndrome, and neurodegenerative diseases like Parkinson’s. Antibodies targeting NDUFS5 enable researchers to detect protein expression, assess Complex I assembly, and investigate mitochondrial dysfunction in disease models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore metabolic pathways, oxidative stress responses, and therapeutic interventions. Given the growing interest in mitochondrial biology and metabolic diseases, the NDUFS5 antibody serves as a vital reagent for elucidating molecular mechanisms underlying energy metabolism defects and developing diagnostic or therapeutic strategies. Its specificity and reliability make it indispensable for studies focusing on cellular bioenergetics and mitochondrial-related pathologies.