| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NLG1; NEPH3; FILTRIN |
| WB Predicted band size | 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human KIRREL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIRREL2抗体的3篇参考文献示例(内容基于假设性文献概括，供参考)：
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1. **文献名称**：*KIRREL2 expression in renal cell carcinoma and its interaction with the Hippo signaling pathway*
**作者**：Lee, S., et al.
**摘要**：本研究利用特异性KIRREL2抗体，揭示了KIRREL2在肾癌细胞中的异常高表达，并发现其通过调控Hippo通路关键分子(如YAP1)影响肿瘤侵袭性，提示其作为潜在治疗靶点的可能性。
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2. **文献名称**：*Development and validation of a monoclonal antibody against human KIRREL2 for immunohistochemical applications*
**作者**：Zhang, Y., et al.
**摘要**：作者开发了一种高特异性抗人KIRREL2单克隆抗体，验证了其在Western blot、免疫组化中的可靠性，并证实KIRREL2在正常肾脏组织与肿瘤微环境中的差异定位，为病理诊断提供了新工具。
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3. **文献名称**：*KIRREL2 mediates germ cell-sertoli cell adhesion during testis development*
**作者**：Garcia, J., et al.
**摘要**：通过KIRREL2抗体的免疫荧光染色，研究发现KIRREL2在睾丸支持细胞中特异性表达，调控生殖细胞与支持细胞的黏附过程，其缺失导致小鼠精子发生异常，强调了其在生殖发育中的关键作用。
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**备注**：以上文献为示例性质，实际引用时需通过PubMed、Web of Science等数据库检索真实文献(可用关键词“KIRREL2 antibody”或“KIRREL2 + 研究领域”筛选)。若需具体文献协助，可提供更多上下文信息。
KIRREL2 (Kin of IRRE-like 2), also known as NEPH3. is a transmembrane protein belonging to the immunoglobulin superfamily. It shares structural homology with other KIRREL family members, featuring extracellular immunoglobulin-like domains, a single-pass transmembrane region, and a cytoplasmic tail involved in signaling interactions. Primarily expressed in podocytes of the kidney glomerulus, KIRREL2 plays a critical role in maintaining the filtration barrier by mediating cell-matrix adhesion and slit diaphragm organization. It interacts with nephrin and podocin, key proteins in glomerular function, and contributes to actin cytoskeleton regulation.
Antibodies targeting KIRREL2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate kidney diseases such as nephrotic syndrome, diabetic nephropathy, and congenital glomerulopathies. Recent studies also implicate KIRREL2 in cancer progression, particularly in metastasis and cell adhesion mechanisms, spurring interest in its potential as a biomarker. Commercial KIRREL2 antibodies are typically raised in rabbits or mice, with validation in knockout models to ensure specificity. Ongoing research aims to clarify its roles beyond the kidney, including neural and immune systems, highlighting its broader biological significance.
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