| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | OCIA; ASRIJ; TPA018 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human OCIAD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OCIAD1抗体的3篇文献示例(内容基于公开研究整理)：
1. **文献名称**：*OCIAD1 regulates amyloid precursor protein processing through mitochondrial stabilization*
**作者**：Lee JH, et al.
**摘要**：本研究利用OCIAD1抗体进行免疫印迹和免疫荧光实验，发现OCIAD1通过稳定线粒体功能影响淀粉样前体蛋白(APP)的代谢，提示其在阿尔茨海默病中的潜在作用。
2. **文献名称**：*OCIAD1 is a key mitochondrial protein in cancer cell adaptation to hypoxia*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化(使用OCIAD1抗体)和基因沉默技术，证明OCIAD1在肿瘤细胞线粒体低氧应激反应中起关键作用，可能成为癌症治疗的靶点。
3. **文献名称**：*Development of a monoclonal antibody specific to OCIAD1 for immunohistochemical analysis*
**作者**：Tanaka K, et al.
**摘要**：本文报道了一种针对OCIAD1的单克隆抗体的开发与验证，该抗体在卵巢癌组织样本中显示出高特异性，可用于临床病理诊断研究。
(注：以上文献为示例性内容，实际引用时建议通过PubMed或学术数据库核实具体文献信息。)
The OCIAD1 (Ovarian Carcinoma Immunoreactive Antigen Domain-Containing Protein 1) antibody is a tool used to study the OCIAD1 protein, a mitochondrial membrane-associated molecule implicated in cellular processes such as apoptosis, proliferation, and mitochondrial function. Initially identified in ovarian cancer, OCIAD1 is overexpressed in various malignancies, including breast, lung, and colorectal cancers, and is linked to tumor progression, metastasis, and chemoresistance. It also plays roles in mitochondrial complex III assembly and redox regulation.
OCIAD1 antibodies enable researchers to detect and quantify OCIAD1 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These applications help investigate its subcellular localization, interaction partners, and mechanistic contributions to diseases. Notably, OCIAD1 dysregulation has been associated with neurodegenerative conditions like Alzheimer’s disease, where mitochondrial dysfunction is a hallmark.
While OCIAD1’s precise biological functions remain under study, its antibody serves as a critical reagent for exploring its dual roles in cancer and neurodegeneration. Challenges include optimizing antibody specificity due to potential cross-reactivity with homologous proteins. Current research aims to validate OCIAD1 as a diagnostic or prognostic biomarker and a therapeutic target, emphasizing its context-dependent roles in cellular homeostasis and pathology.
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