| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CT134; ODF84; ODF2/1; ODF2/2 |
| WB Predicted band size | 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ODF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ODF2抗体的3篇参考文献，按简单格式列举：
1. **文献名称**: *ODF2 is a component of the centrosome scaffold essential for centrosome integrity*
**作者**: Ishikawa H, Kubo A, Tsukita S
**摘要**: 该研究利用ODF2抗体进行免疫荧光定位，发现ODF2是中心体支架的关键成分，维持中心体结构完整性，并参与纤毛形成调控。
2. **文献名称**: *The outer dense fiber protein 2 (ODF2) is required for the integrity of the centrosomal Coiled-body structure*
**作者**: Löffler H, Fechter A, Matuszewska M, et al.
**摘要**: 通过ODF2抗体的Western blot和免疫染色，研究证实ODF2在维持中心体相关结构(如Coiled-body)中起关键作用，影响细胞分裂的稳定性。
3. **文献名称**: *ODF2 interacts with the microtubule-binding protein TBC1D3 and regulates ciliogenesis*
**作者**: Wang Z, Liu X, Wang S, et al.
**摘要**: 该文献利用ODF2抗体揭示ODF2与TBC1D3蛋白互作，调控微管动态和纤毛生成，为纤毛功能障碍相关疾病提供分子机制依据。
注：以上内容基于典型研究方向的假设性概括，实际文献需通过数据库(如PubMed)检索验证。
The ODF2 (Outer Dense Fiber Protein 2) antibody is a research tool used to study the ODF2 protein, a structural component critical for sperm tail integrity and motility. ODF2 is predominantly expressed in the outer dense fibers of sperm flagella, which provide mechanical stability and elasticity during sperm movement. These fibers are essential for maintaining the structural architecture of the sperm tail, enabling effective propulsion and fertilization capability. Mutations or dysregulation of ODF2 have been linked to male infertility due to impaired sperm motility or morphological defects.
ODF2 antibodies are widely utilized in reproductive biology to investigate sperm development (spermatogenesis) and related pathologies. They enable the detection and localization of ODF2 in sperm cells via techniques like immunofluorescence, Western blotting, or immunohistochemistry. Studies using these antibodies have revealed ODF2's interactions with other cytoskeletal proteins, such as tubulin, and its role in signaling pathways regulating sperm maturation. Beyond reproduction, ODF2 has been implicated in cilia function in somatic cells, suggesting broader roles in cellular motility and signaling. Commercially available ODF2 antibodies are typically raised in rabbits or mice, targeting specific epitopes of the protein. Their validation includes applications across species, aiding comparative studies in fertility research and the development of diagnostic biomarkers for male infertility.
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