| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNX11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX11抗体的3篇模拟参考文献示例(实际文献可能需要通过学术数据库检索确认)：
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1. **文献名称**: *"Sorting Nexin 11 regulates lysosomal degradation of epidermal growth factor receptor through interaction with ubiquitinated cargo"*
**作者**: Li Y et al.
**摘要**: 本研究利用SNX11特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了SNX11通过其PX结构域与泛素化的EGFR结合，促进受体向溶酶体运输并调控其降解的分子机制。
2. **文献名称**: *"SNX11 modulates endosomal trafficking and β-amyloid production in Alzheimer's disease models"*
**作者**: Smith JR et al.
**摘要**: 通过Western blot和免疫组化实验，作者发现SNX11抗体检测到其在神经元中的表达升高与β-淀粉样蛋白沉积相关。SNX11可能通过调控APP蛋白的运输影响阿尔茨海默病的病理进程。
3. **文献名称**: *"Functional characterization of Sorting Nexin 11 in cancer cell invasion using CRISPR-Cas9 and antibody-based assays"*
**作者**: Chen L et al.
**摘要**: 研究利用SNX11抗体进行流式细胞术和细胞迁移实验，证明SNX11缺失会增强癌细胞侵袭能力，其机制可能与整合素信号通路的异常激活有关。
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**注意**：以上为示例文献，实际研究中请通过PubMed、Google Scholar等平台以关键词“SNX11 antibody”或“Sorting Nexin 11”检索最新论文。如需具体文献，建议提供更详细的研究方向以便精准推荐。
The SNX11 (Sorting Nexin 11) antibody is a tool used to study the SNX11 protein, a member of the sorting nexin family involved in intracellular membrane trafficking and protein sorting. SNX11 contains a characteristic phox homology (PX) domain, which facilitates lipid binding and membrane association, and may participate in endosomal sorting, vesicle formation, or receptor trafficking. While less well-characterized than other sorting nexins (e.g., SNX1 or SNX3), SNX11 has been implicated in regulating endosome-to-lysosome transport, autophagy, and receptor degradation pathways. Studies suggest its potential role in cellular processes such as cytokine secretion, neuronal function, and cancer progression, though its precise mechanisms remain under investigation.
SNX11 antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, localization, and interactions. These antibodies help researchers explore SNX11's involvement in diseases, including neurodegenerative disorders and cancers, where trafficking dysregulation may contribute to pathogenesis. Many commercially available SNX11 antibodies are raised against specific epitopes, often in rabbits or mice, and validated for reactivity in human, mouse, or rat samples. Proper validation (e.g., knockout controls) is critical due to potential cross-reactivity with other sorting nexins. Ongoing research aims to clarify SNX11's functional diversity and therapeutic relevance in cellular homeostasis and disease.
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