Rabbit Polyclonal SNX12 Antibody

The SNX12 antibody is a tool used to detect Sorting Nexin 12 (SNX12), a member of the sorting nexin family involved in intracellular membrane trafficking and protein sorting. SNX12 contains a characteristic Phox homology (PX) domain, enabling lipid binding—particularly to phosphatidylinositol-3-phosphate (PtdIns3P)—to localize to endosomal membranes. It plays roles in endosomal sorting, vesicle formation, and receptor trafficking, potentially influencing cellular processes like signal transduction, receptor recycling, and lysosomal degradation. SNX12 antibodies are typically developed in hosts such as rabbits or mice, targeting specific epitopes of the protein for applications like Western blotting, immunofluorescence, or immunohistochemistry. These antibodies help researchers study SNX12's expression patterns, subcellular localization, and interactions with other trafficking-related proteins (e.g., retromer complex components). Dysregulation of SNX12 has been loosely linked to neurological disorders and cancer, though its precise pathological mechanisms remain under investigation. Validated SNX12 antibodies are essential for exploring its functional contributions to cellular homeostasis and disease, often requiring specificity checks via knockout controls. Commercial variants may include monoclonal or polyclonal formats, with reactivity across human, mouse, or rat samples depending on design.