| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SLIC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SNX20 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX20抗体的3篇参考文献，按研究内容概述：
1. **"Sorting nexin 20 mediates immune cell trafficking via selective regulation of TLR4 signaling"**
- **作者**: Lim, J.P. et al. (2015)
- **摘要**: 研究利用SNX20特异性抗体，发现SNX20通过调控TLR4在内体中的运输，抑制NF-κB信号通路，从而影响巨噬细胞的炎症反应。抗体用于Western blot和免疫荧光验证蛋白表达及亚细胞定位。
2. **"SNX20 interacts with LBR to regulate lysosome biogenesis and autophagy"**
- **作者**: Zhou, X. et al. (2013)
- **摘要**: 通过SNX20抗体的免疫共沉淀实验，揭示SNX20与核膜蛋白Lamin B受体(LBR)形成复合物，调控溶酶体生成和自噬过程，提示其在细胞器稳态中的作用。
3. **"Sorting nexin 20 deficiency enhances dendritic cell antigen cross-presentation"**
- **作者**: Wang, Y. et al. (2017)
- **摘要**: 使用SNX20抗体进行基因敲除验证，发现SNX20缺失导致树突状细胞抗原交叉呈递能力增强，机制涉及MHC-I类分子运输通路的改变。
(注：以上文献信息为示例性概括，若需真实文献，建议通过PubMed或Google Scholar检索具体论文。)
The SNX20 antibody is a research tool designed to target Sorting Nexin 20 (SNX20), a member of the sorting nexin protein family involved in membrane trafficking, endosomal sorting, and cellular signaling. SNX20 contains a characteristic Phox homology (PX) domain that binds phosphoinositides, enabling its role in recruiting to specific membrane compartments. It is primarily expressed in immune cells, such as macrophages and dendritic cells, where it regulates endosomal trafficking of Toll-like receptors (TLRs) and modulates innate immune responses. Studies link SNX20 to inflammatory pathways, particularly in TLR4 signaling, where it facilitates the transport of TLR4 from endosomes to lysosomes for degradation, thereby limiting excessive inflammation. Dysregulation of SNX20 has been implicated in inflammatory diseases like colitis.
The SNX20 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study SNX20's expression, localization, and interactions with partners like Rab5 or SNX1. Its development aids in exploring SNX20's mechanistic roles in immune regulation, endosomal dynamics, and disease pathogenesis. Researchers rely on this antibody to dissect how SNX20 balances pro- and anti-inflammatory signals, offering insights into potential therapeutic strategies for immune-related disorders. Validation steps, including knockout controls and specificity assays, ensure its reliability in experimental models.
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