| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ST1; MDA9; SYCL; MDA-9; TACIP18 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SDCBP抗体的3篇示例文献(注：文献信息为模拟概括，具体内容请参考实际数据库检索)：
1. **文献名称**：*SDCBP interacts with EGFR to promote breast cancer metastasis via modulation of exosome biogenesis*
**作者**：Li Y, et al.
**摘要**：该研究利用SDCBP抗体通过免疫共沉淀和Western blot技术，揭示了SDCBP与EGFR在乳腺癌细胞中的相互作用，证实其通过调控外泌体分泌促进肿瘤转移。
2. **文献名称**：*Syndecan-binding protein (SDCBP) is a novel biomarker in hepatocellular carcinoma progression*
**作者**：Wang X, et al.
**摘要**：通过免疫组化(IHC)和SDCBP抗体检测肝细胞癌组织样本，发现SDCBP高表达与患者预后不良相关，并参与调控VEGF信号通路驱动的血管生成。
3. **文献名称**：*SDCBP modulates TGF-β signaling in hepatic stellate cells and exacerbates liver fibrosis*
**作者**：Zhang H, et al.
**摘要**：研究使用SDCBP抗体在小鼠肝纤维化模型中验证其表达上调，并通过体外实验表明SDCBP通过增强TGF-β/Smad通路活性促进纤维化进程。
如需具体文献，建议在PubMed或Web of Science中检索关键词“SDCBP antibody”或“SDCBP immunohistochemistry”获取最新研究。
The syndecan binding protein (SDCBP), also known as STOML2 or syntenin-1. is a cytosolic adaptor protein involved in cellular adhesion, membrane trafficking, and signal transduction. It contains two PDZ domains that enable interactions with the cytoplasmic tails of syndecans, a family of transmembrane heparan sulfate proteoglycans critical for extracellular matrix (ECM) communication. SDCBP mediates syndecan-dependent processes, including cytoskeletal organization, exosome biogenesis, and receptor tyrosine kinase signaling, by bridging syndecans to intracellular effectors like kinases or cytoskeletal proteins.
SDCBP antibodies are essential tools for studying its role in pathological conditions. Overexpression of SDCBP is linked to cancer progression, particularly in melanoma, breast, and colorectal cancers, where it promotes metastasis by enhancing ECM degradation and cell migration. It also interacts with viral proteins (e.g., HIV-1 Tat, HPV E6), facilitating viral entry or release. In neurodegenerative diseases, SDCBP regulates synaptic protein clustering and neuronal signaling.
These antibodies are widely used in Western blotting, immunoprecipitation, and immunofluorescence to detect SDCBP expression levels, localization, and binding partners in cell lysates or tissues. Monoclonal antibodies offer high specificity, while polyclonal antibodies may capture diverse isoforms. Validation often includes knockout/knockdown controls or overexpression assays. Researchers prioritize antibodies with minimal cross-reactivity to related PDZ-domain proteins (e.g., SDCBP2) to ensure accurate experimental outcomes in studying SDCBP's multifaceted roles.
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