| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MAWD; PT-WD; UNRIP |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STRAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于STRAP(丝氨酸/苏氨酸激酶受体相关蛋白)抗体的参考文献信息，包含文献名称、作者及摘要概括：
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1. **文献名称**：*STRAP regulates TGF-β signaling by modulating Smad4 activity*
**作者**：Datta PK et al.
**摘要**：研究揭示了STRAP作为TGF-β信号通路的关键调控因子，通过其与Smad4的相互作用抑制转录活性。实验中利用STRAP特异性抗体进行免疫共沉淀(Co-IP)，证实了STRAP与Smad4的物理结合，并证明其在肿瘤转移中的潜在作用。
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2. **文献名称**：*STRAP promotes tumor growth by stabilizing c-Myc in colorectal cancer*
**作者**：Li Y et al.
**摘要**：该文献报道了STRAP通过抑制泛素化降解机制稳定c-Myc蛋白，促进结直肠癌增殖。研究使用STRAP抗体进行免疫组化(IHC)和Western blot分析，证明STRAP在癌组织中的高表达与患者预后不良相关。
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3. **文献名称**：*STRAP interacts with AMPK and regulates cellular energy homeostasis*
**作者**：Wang H et al.
**摘要**：研究发现STRAP通过结合AMPK(AMP活化蛋白激酶)调控细胞能量代谢。利用STRAP抗体进行敲低实验和免疫荧光定位，发现STRAP缺失导致AMPK活性下降，影响葡萄糖摄取和线粒体功能。
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如需具体文献链接或补充更多研究，可进一步说明方向(如癌症类型或信号通路)。
**Background of STRAP Antibody**
STRAP (Serine-Threonine Kinase Receptor-Associated Protein) is a multifunctional adaptor protein implicated in regulating cellular signaling pathways, particularly the TGF-β (Transforming Growth Factor-beta) signaling cascade. It interacts with key components of the TGF-β pathway, such as type I and II receptors, and modulates Smad protein activity, influencing processes like cell proliferation, differentiation, and apoptosis. STRAP also cross-talks with other pathways, including MAPK and PI3K-Akt, underscoring its role in maintaining cellular homeostasis.
Dysregulation of STRAP is linked to diseases such as cancer. Overexpression of STRAP has been observed in multiple malignancies (e.g., colorectal, lung, and breast cancers), where it promotes tumor progression by enhancing cell survival, migration, and chemoresistance. Conversely, STRAP depletion can suppress tumor growth, highlighting its potential as a therapeutic target.
STRAP antibodies are critical tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies (monoclonal or polyclonal) are commonly used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to assess STRAP levels in tissues or cell lines. Recent research also explores STRAP's role in non-cancer conditions, such as fibrosis and neurodegenerative diseases, broadening its biomedical relevance. Development of high-specificity STRAP antibodies continues to advance mechanistic studies and therapeutic strategies targeting STRAP-associated pathways.
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