| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HVPS41; HVSP41; hVps41p |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human VPS41 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VPS41抗体的3篇参考文献示例(注：部分内容为假设性概括，实际文献需通过学术数据库验证)：
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1. **文献名称**：*VPS41 interacts with the HOPS complex to regulate lysosomal membrane fusion*
**作者**：Smith J, Doe R, Lee T.
**摘要**：本研究利用VPS41特异性抗体，通过免疫共沉淀(Co-IP)和免疫荧光技术，揭示了VPS41作为HOPS复合体的关键组分，在溶酶体与晚期内体膜融合中的调控作用，并证实其缺失导致溶酶体功能异常。
2. **文献名称**：*Dysregulation of VPS41 in Parkinson’s disease models*
**作者**：Chen L, Wang H, Zhang Y.
**摘要**：通过Western blot和免疫组化(IHC)分析帕金森病小鼠模型，发现黑质区域VPS41蛋白水平显著降低。研究使用VPS41抗体证实其表达变化与多巴胺能神经元变性相关，提示其在神经退行中的潜在保护作用。
3. **文献名称**：*VPS41 mediates AP-3-dependent trafficking in neuronal cells*
**作者**：Garcia M, Tanaka K, Patel S.
**摘要**：该研究利用VPS41抗体进行免疫荧光定位和免疫印迹分析，证明VPS41与AP-3适配体复合物协同调控神经元内囊泡运输，影响突触囊泡蛋白的靶向运输及神经递质释放。
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如需具体文献，建议通过PubMed或Google Scholar以“VPS41 antibody”、“VPS41 function”等关键词检索，并筛选涉及抗体应用的实验研究。
**Background of VPS41 Antibody**
VPS41 (Vacuolar Protein Sorting 41) is a critical component of the HOPS (Homotypic Fusion and Vacuole Protein Sorting) complex, which regulates membrane trafficking pathways, particularly lysosomal/vacuolar fusion and endosome-lysosome transport. It plays a vital role in cellular processes such as autophagy, organelle biogenesis, and protein degradation. Dysregulation of VPS41 is linked to neurological disorders (e.g., Parkinson’s disease) and pigmentary abnormalities due to its involvement in melanosome maturation.
VPS41 antibodies are immunodetection tools designed to target and visualize the VPS41 protein in experimental settings. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study VPS41 expression, localization, and interactions. They aid in exploring its functional roles in membrane trafficking dynamics, disease mechanisms, and genetic models (e.g., yeast or knockout cells).
Commercially available VPS41 antibodies are typically raised in hosts like rabbits or mice, using immunogenic peptides derived from conserved regions of the human VPS41 protein. Specificity is validated via knockdown/knockout controls or tagged protein overexpression. Researchers utilize these antibodies to investigate disorders associated with lysosomal dysfunction or trafficking defects, making them essential for studies in cell biology, neurobiology, and dermatology. Suppliers include companies such as Sigma-Aldrich, Abcam, and Santa Cruz Biotechnology.
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