| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HL2; HL-2 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ITLN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITLN2抗体的3篇参考文献示例(文献信息为虚构示例，仅供参考格式)：
1. **文献名称**: *"Intelectin-2 (ITLN2) as a novel biomarker in obesity-associated metabolic disorders"*
**作者**: Smith A, et al.
**摘要**: 本研究利用ITLN2多克隆抗体，通过免疫组化和Western blot技术，揭示了ITLN2在肥胖患者脂肪组织中的高表达及其与胰岛素抵抗的相关性。
2. **文献名称**: *"Role of ITLN2 in intestinal inflammation: Insights from antibody-mediated functional studies"*
**作者**: Chen L, et al.
**摘要**: 通过抗ITLN2单克隆抗体阻断实验，发现ITLN2通过调节肠道黏膜免疫细胞活性参与炎症性肠病的病理过程，为治疗靶点提供依据。
3. **文献名称**: *"Development and validation of a high-specificity ITLN2 antibody for cancer biomarker research"*
**作者**: Tanaka K, et al.
**摘要**: 本研究报道了一种新型抗ITLN2单克隆抗体的开发，验证其在结直肠癌组织中的高特异性识别能力，并证明ITLN2表达与肿瘤进展相关。
4. **文献名称**: *"ITLN2 in respiratory immunity: Localization and functional analysis using antibody-based imaging"*
**作者**: Müller S, et al.
**摘要**: 利用抗ITLN2抗体进行免疫荧光定位，发现其在呼吸道黏膜中的表达模式，提示其可能在抗病原体先天免疫中发挥作用。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed、Google Scholar等。)
ITLN2 (Intelectin-2) is a calcium-dependent lectin protein encoded by the ITLN2 gene, primarily expressed in the human intestine, adipose tissue, and placenta. It belongs to the intelectin family, which plays roles in innate immunity, pathogen recognition, and metabolic regulation. ITLN2 binds to carbohydrate moieties on microbial surfaces, such as galactofuranose in bacterial cell walls, suggesting its involvement in host defense against pathogens. Structurally, it forms trimers with fibrinogen-like domains, facilitating interactions with microbial glycans and endogenous ligands.
Research highlights ITLN2's dual role in immunity and metabolism. It is implicated in inflammatory bowel disease (IBD), obesity, and type 2 diabetes, with altered expression levels observed in these conditions. For instance, ITLN2 may modulate adipose tissue inflammation and insulin sensitivity, linking metabolic dysfunction to immune responses. Its expression is regulated by cytokines (e.g., IL-13) and gut microbiota, emphasizing its connection to mucosal immunity.
ITLN2 antibodies are essential tools for detecting and quantifying the protein in research. They enable studies on its tissue distribution, functional mechanisms, and disease associations. Polyclonal and monoclonal antibodies are used in techniques like Western blotting, immunohistochemistry, and ELISA. Some antibodies target specific epitopes within the fibrinogen-like or lectin domains, aiding in functional studies. Species-specific variants (human, mouse, rat) are available, with validation in recombinant proteins or knockout models to ensure specificity. Ongoing research leverages ITLN2 antibodies to explore its therapeutic potential in metabolic disorders and infections.
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