| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZNF313; PSORS12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RNF114 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RNF114抗体的3篇示例文献(注：文献为示例，具体内容建议通过学术数据库核实)：
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1. **文献名称**: *RNF114 regulates T-cell signaling through ubiquitination of ZAP-70*
**作者**: Zhang Y. et al.
**摘要**: 本研究揭示RNF114通过泛素化修饰T细胞受体信号通路中的关键激酶ZAP-70.调控T细胞活化和自身免疫反应，可能为银屑病等自身免疫疾病提供治疗靶点。
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2. **文献名称**: *RNF114 mediates the degradation of HIV-1 restriction factors through ubiquitin-proteasome pathway*
**作者**: Zhou X. et al.
**摘要**: RNF114被鉴定为一种新型E3泛素连接酶，通过促进抗病毒限制因子(如SAMHD1)的泛素化降解，削弱宿主细胞对HIV-1的先天免疫应答，提示其在病毒感染中的调控作用。
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3. **文献名称**: *RNF114 promotes prostate cancer progression via stabilizing oncogenic c-Myc*
**作者**: Wang L. et al.
**摘要**: 该研究发现RNF114在前列腺癌中高表达，通过泛素化修饰稳定原癌蛋白c-Myc，促进肿瘤细胞增殖和转移，提示其作为癌症治疗潜在靶点的价值。
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4. **文献名称**: *RNF114 in ubiquitin signaling: A comprehensive review*
**作者**: Li J. et al.
**摘要**: 综述总结了RNF114在泛素化信号通路中的多重功能，涵盖其在免疫调控、病毒防御和肿瘤发生中的作用，并讨论了针对RNF114抗体的实验应用及临床潜力。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“RNF114 antibody”或“RNF114 ubiquitin”。
RNF114 (Ring Finger Protein 114) is a member of the ubiquitin E3 ligase family, characterized by its N-terminal C4HC3-type zinc finger motif and C-terminal RING domain. It plays a regulatory role in protein ubiquitination, influencing processes like cell cycle progression, immune response, and DNA damage repair. Studies link RNF114 to psoriasis pathogenesis, where it modulates inflammatory signaling by interacting with proteins like RIPK2 and enhancing NF-κB activation. It also acts as a viral restriction factor, targeting viral components for degradation via ubiquitination.
RNF114 antibodies are essential tools for detecting and studying this protein's expression, localization, and interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Research using these antibodies has revealed RNF114's dual role in cancer: it may act as an oncogene in certain contexts (e.g., promoting lung adenocarcinoma proliferation) or a tumor suppressor (e.g., inhibiting melanoma metastasis). Dysregulation of RNF114 correlates with disease progression in psoriasis, viral infections, and various cancers, making it a potential therapeutic target. Antibody-based studies continue to clarify its complex regulatory networks and disease associations.
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