首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal POLDIP3 Antibody

  • 中文名: POLDIP3抗体
  • 别    名: SKAR; PDIP3; PDIP46
货号: IPDX09182
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与POLDIP3抗体相关的文献摘要信息(示例基于公开文献数据整理,部分为虚构示例):

---

1. **文献名称**: *POLDIP3 regulates oxidative stress-induced genome instability by interacting with the PCNA*

**作者**: Smith A, et al.

**摘要**: 本研究利用POLDIP3抗体通过免疫共沉淀技术,揭示了POLDIP3通过与PCNA结合,在氧化应激条件下维持基因组稳定性,并调控DNA损伤修复通路的机制。

---

2. **文献名称**: *POLDIP3 modulates mRNA splicing and cell cycle progression in mammalian cells*

**作者**: Chen L, et al.

**摘要**: 通过Western blot和免疫荧光技术(使用POLDIP3特异性抗体),作者发现POLDIP3与剪接体复合物相互作用,影响mRNA剪接效率,并调控G1/S期细胞周期转换。

---

3. **文献名称**: *A role for POLDIP3 in mitochondrial function and cellular senescence*

**作者**: Garcia-Ruiz C, et al.

**摘要**: 该研究通过敲低和过表达实验结合POLDIP3抗体检测,证明POLDIP3通过调节线粒体ROS产生延缓细胞衰老,为代谢相关疾病提供潜在治疗靶点。

---

注:以上文献为示例性质,实际引用需以具体论文数据为准。建议通过PubMed或Google Scholar检索关键词“POLDIP3 antibody”或“POLDIP3 function”获取最新文献。

背景信息

POLDIP3 (DNA Polymerase Delta Interacting Protein 3), also known as PDIP46 or SKAR, is a multifunctional protein involved in DNA replication, repair, and mRNA processing. It interacts with DNA polymerase δ to facilitate DNA synthesis and repair, while also participating in mTOR-mediated translational regulation by linking mRNA splicing to protein synthesis. POLDIP3 antibodies are essential tools for studying its roles in cellular processes such as genome stability, cell cycle progression, and stress responses. These antibodies enable the detection and localization of POLDIP3 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to explore POLDIP3's interactions with partners like PCNA and its involvement in diseases, including cancer and neurodegenerative disorders. Validated antibodies are critical for ensuring specificity, often confirmed through knockout controls or epitope mapping. Understanding POLDIP3's dual functions in nuclear and cytoplasmic pathways highlights its importance in maintaining cellular homeostasis, making targeted antibodies vital for mechanistic studies and potential therapeutic applications.

客户数据及评论

折叠内容

大包装询价

×