Rabbit Polyclonal ZNF496 Antibody

The ZNF496 antibody is a research tool designed to detect and study the Zinc Finger Protein 496 (ZNF496), a member of the zinc finger protein (ZFP) family. ZFPs are characterized by conserved zinc finger domains that mediate DNA, RNA, or protein interactions, often playing roles in transcriptional regulation. ZNF496 contains multiple C2H2-type zinc finger motifs, suggesting its involvement in nucleic acid binding and gene expression modulation. While the specific biological functions of ZNF496 remain under investigation, it is hypothesized to act as a transcriptional repressor or co-regulator, potentially influencing cellular processes like differentiation, apoptosis, or stress responses. Some studies link ZNF496 to the KRAB-ZFP subfamily, known for epigenetic silencing via interactions with chromatin-modifying complexes. Research utilizing ZNF496 antibodies has focused on its expression patterns, subcellular localization (primarily nuclear), and associations with diseases, including cancer and neurodegenerative disorders. For instance, altered ZNF496 expression has been observed in certain tumors, implying a possible role in oncogenesis or tumor suppression. The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ZNF496's molecular interactions and pathways. Its development aids in elucidating ZNF496's contribution to cellular mechanisms and disease pathology, offering potential insights for therapeutic targeting.