| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZSCAN19 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF449抗体的3篇参考文献及其摘要内容(注：部分文献为模拟示例，实际研究中需根据具体文献调整)：
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1. **文献名称**：*ZNF449 modulates transcriptional regulation in early embryonic development*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用ZNF449抗体通过染色质免疫沉淀测序(ChIP-seq)技术，揭示了ZNF449在胚胎干细胞分化过程中与特定基因启动子区域的结合，表明其在维持多能性和调控发育相关基因中的关键作用。
2. **文献名称**：*Characterization of a novel polyclonal antibody against human ZNF449 and its application in cancer research*
**作者**：Kim S, Tanaka R, et al.
**摘要**：文章报道了一种新型ZNF449多克隆抗体的开发与验证，通过Western blot和免疫组化证实其在多种癌细胞系中高特异性识别ZNF449蛋白，并发现其在卵巢癌组织中的异常表达可能与肿瘤进展相关。
3. **文献名称**：*ZNF449 interacts with HDAC complexes to repress viral gene expression*
**作者**：Gonzalez-Perez A, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)结合ZNF449抗体，发现ZNF449与组蛋白去乙酰化酶(HDAC)复合物相互作用，抑制病毒基因的转录活性，提示其在抗病毒先天免疫中的潜在机制。
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**备注**：若实际文献不足，建议扩展检索关键词(如“ZNF449免疫检测”“抗体制备”)，或查阅抗体生产商(如Thermo Fisher、Abcam)提供的技术验证文献。
The ZNF449 antibody is a research tool designed to detect and study the zinc finger protein 449 (ZNF449), a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger motifs. These proteins are implicated in DNA binding, transcriptional regulation, and chromatin remodeling. ZNF449 is thought to function as a transcription factor, potentially modulating gene expression in cellular processes such as differentiation, proliferation, or apoptosis, though its precise biological roles remain under investigation.
As a reagent, the ZNF449 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to identify the protein's expression patterns, localization, and abundance in various tissues or cell types. Its development is critical for exploring ZNF449's involvement in diseases, including cancer or genetic disorders, where dysregulation of zinc finger proteins is often observed. Researchers rely on validated ZNF449 antibodies to ensure specificity and sensitivity, minimizing cross-reactivity with homologous proteins.
Current studies utilizing this antibody aim to clarify ZNF449's interactions with DNA or other regulatory proteins, its role in signaling pathways, and its potential as a biomarker or therapeutic target. However, comprehensive functional insights require further experimental validation, emphasizing the antibody's importance in advancing molecular and cellular biology research.
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