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Rabbit Polyclonal CD55 Antibody

  • 中文名: CD55抗体
  • 别    名: CR; TC; DAF; CROM
货号: IPDX09261
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3-4条关于CD55抗体的参考文献示例(内容为模拟生成,非真实文献):

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1. **文献名称**:*CD55 as a Therapeutic Target in Colorectal Cancer*

**作者**:Smith A, et al.

**摘要**:研究探讨了CD55在结直肠癌细胞中的过表达及其对补体介导的细胞毒性的抑制作用。通过使用抗CD55单克隆抗体阻断其功能,可增强补体依赖的肿瘤细胞杀伤效果,为靶向治疗提供新策略。

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2. **文献名称**:*Anti-CD55 Antibodies Protect Erythrocytes from Complement-Mediated Lysis*

**作者**:Lee B, et al.

**摘要**:本文发现特定抗CD55抗体可通过稳定细胞膜表面的CD55蛋白,减少补体系统过度激活导致的溶血现象,为治疗阵发性睡眠性血红蛋白尿症(PNH)提供实验依据。

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3. **文献名称**:*CD55 Modulates Autoimmune Responses via Regulatory T Cells*

**作者**:Wang C, et al.

**摘要**:研究利用抗CD55抗体干预小鼠模型,证明CD55通过调控Treg细胞的活性影响自身免疫疾病进展,揭示其在类风湿性关节炎中的潜在治疗价值。

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4. **文献名称**:*CD55-Dependent Viral Evasion Mechanisms in COVID-19*

**作者**:Zhang Y, et al.

**摘要**:该文献报道新冠病毒通过劫持宿主CD55蛋白逃避免疫攻击,并证明抗CD55抗体可阻断这一过程,为抗病毒治疗提供新思路。

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(注:以上文献信息为示例性内容,实际引用需查询真实数据库如PubMed、Web of Science等。)

背景信息

CD55. also known as decay-accelerating factor (DAF), is a membrane-bound glycoprotein that regulates the complement system by inhibiting the formation of C3/C5 convertases, thereby protecting host cells from unintended complement-mediated damage. Expressed widely on blood cells, endothelial cells, and epithelial surfaces, CD55 plays a critical role in maintaining immune homeostasis. Antibodies targeting CD55 have garnered interest in both research and clinical contexts. In research, anti-CD55 antibodies are used as tools to study complement regulation, immune evasion mechanisms in pathogens or cancer, and cellular signaling pathways linked to CD55. Clinically, CD55 dysfunction is associated with diseases like paroxysmal nocturnal hemoglobinuria (PNH), where deficient CD55 expression leads to complement-driven hemolysis. Anti-CD55 antibodies may also have therapeutic potential; for example, they are explored in cancer immunotherapy to block CD55-mediated immune resistance or to deliver targeted treatments. Additionally, CD55 serves as a receptor for certain viruses (e.g., enteroviruses), making its antibodies relevant in studying viral entry mechanisms. Monoclonal anti-CD55 antibodies, such as clones like BRIC110 or IA10. are commonly utilized in flow cytometry and immunohistochemistry to assess CD55 expression in diseases. Overall, CD55 antibodies bridge fundamental immunology with translational applications in autoimmunity, oncology, and infectious diseases.

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