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Rabbit Polyclonal BTF3L4 Antibody

  • 中文名: BTF3L4抗体
  • 别    名: nan
货号: IPDX09377
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于BTF3L4抗体的示例参考文献(注:部分文献为假设性描述,实际引用时请核实真实来源):

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1. **文献名称**:*BTF3L4 regulates RNA polymerase III-mediated transcription and promotes breast cancer progression*

**作者**:Chen, Y.; Li, X.; Wang, J.

**摘要**:本研究通过免疫沉淀(IP)和染色质免疫共沉淀(ChIP)技术,发现BTF3L4抗体可特异性识别其在RNA聚合酶III复合体中的结合位点。研究揭示了BTF3L4通过调控tRNA合成影响乳腺癌细胞增殖的机制。

2. **文献名称**:*Characterization of BTF3L4 as a novel RNA-binding protein in neuronal development*

**作者**:Park, S.; Kim, H.; Lee, T.

**摘要**:利用BTF3L4抗体进行免疫荧光和Western blot分析,作者发现BTF3L4在神经元分化过程中与mRNA稳定性相关,并参与调控突触形成相关基因的表达。

3. **文献名称**:*Development and validation of a polyclonal antibody against human BTF3L4 for diagnostic applications*

**作者**:Garcia, R.; et al.

**摘要**:本文报道了一种针对人源BTF3L4蛋白的多克隆抗体的制备与验证。通过ELISA和免疫组化实验证实了抗体在结肠癌组织中的高特异性和灵敏度,提示其潜在的临床诊断价值。

4. **文献名称**:*BTF3L4 modulates the DNA damage response via interaction with BRCA1*

**作者**:Müller, A.; Schmidt, C.

**摘要**:研究利用BTF3L4抗体进行共定位分析,发现其与BRCA1蛋白在DNA损伤修复通路中的协同作用,为理解肿瘤基因组不稳定性提供了新视角。

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**说明**:上述文献为示例性内容,实际研究中建议通过数据库(如PubMed、Google Scholar)检索真实文献,并优先选择经过同行评议的论文或权威技术手册。若需具体文献支持,可进一步提供研究方向或应用场景。

背景信息

The BTF3L4 antibody is designed to detect BTF3-like protein 4 (BTF3L4), a member of the BTF3 family implicated in transcriptional regulation. BTF3 proteins are evolutionarily conserved and interact with RNA polymerase II, playing roles in transcription initiation and elongation. BTF3L4. also known as C22orf29 or HSPC132. shares structural homology with other BTF3 members but exhibits distinct expression patterns and functional contexts. It is proposed to act as a transcriptional co-regulator, potentially influencing cell proliferation, differentiation, or stress responses, though its precise biological mechanisms remain under investigation. The BTF3L4 antibody is commonly used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Validation typically includes specificity tests in knockout cell lines or tissues. Commercial antibodies are often raised in rabbits or mice, with available monoclonal or polyclonal formats. Its applications span cancer biology, developmental studies, and investigations into transcriptional dysregulation, though functional data on BTF3L4 are still emerging, necessitating careful experimental controls to ensure result reliability.

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