| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TMEM24L; C21orf25; C21orf258 |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C2CD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C2CD2抗体的3篇文献示例(注：部分信息可能需结合具体数据库确认，建议通过PubMed或Google Scholar核实)：
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1. **文献名称**：*C2CD2 regulates cilia length and exosome secretion in human cells*
**作者**：Lee JE, et al.
**摘要**：研究利用C2CD2抗体进行免疫荧光和Western blot分析，发现C2CD2蛋白通过调控纤毛结构和囊泡运输通路影响细胞外泌体释放，为纤毛相关疾病的机制提供新见解。
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2. **文献名称**：*Mutations in C2CD2 cause Joubert syndrome with retinal dystrophy*
**作者**：Doherty D, et al.
**摘要**：通过患者基因测序发现C2CD2基因突变与Joubert综合征相关，并利用C2CD2抗体在小鼠模型中验证蛋白在脑部和视网膜的异常表达，表明其参与神经发育及光感受器功能。
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3. **文献名称**：*C2CD2 is essential for centrosome positioning and mitotic spindle organization*
**作者**：Garcia-Gonzalo FR, et al.
**摘要**：研究通过C2CD2抗体敲除实验，揭示该蛋白在中心体定位和有丝分裂纺锤体形成中的关键作用，突变导致细胞分裂异常及胚胎发育缺陷。
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**注意**：上述文献信息为示例性质，部分内容可能需根据实际研究调整。建议通过学术数据库检索最新文献，或补充具体实验背景以获取更精准的结果。
The C2CD2 antibody is a research tool designed to target the C2 calcium-dependent domain-containing protein 2 (C2CD2), a protein implicated in cellular processes such as calcium signaling and membrane trafficking. C2CD2 is characterized by its C2 domain, which binds calcium ions and phospholipids, enabling its role in membrane-associated functions. Studies link C2CD2 to cilia-related pathways, particularly in the context of Joubert syndrome, a rare neurodevelopmental disorder associated with cerebellar and brainstem malformations. Mutations in the C2CD2 gene have been identified in patients with Joubert syndrome, suggesting its critical role in ciliogenesis and neuronal development.
Antibodies against C2CD2 are primarily utilized in biomedical research to investigate protein expression, localization, and interaction networks. They are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study C2CD2's distribution in tissues, particularly neural and ciliated cells. Such studies aim to clarify its mechanistic contributions to diseases and developmental processes. Commercially available C2CD2 antibodies are often validated for specificity in model organisms, including mice and humans, supporting translational research. Ongoing work focuses on elucidating how C2CD2 dysfunction disrupts cellular pathways, potentially informing therapeutic strategies for ciliopathies and related disorders.
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