Rabbit Polyclonal CFAP298 Antibody

The CFAP298 antibody targets the Cilia and Flagella Associated Protein 298 (CFAP298), a conserved protein implicated in the assembly and function of motile cilia and flagella. CFAP298. also known as TTC12. is part of a multi-protein complex involved in the regulation of dynein arms, critical for ciliary/flagellar motility. Studies suggest its role in cytoplasmic pre-assembly of dynein components before their transport to cilia. Mutations in CFAP298 are linked to ciliopathies, including primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections, infertility, and laterality defects due to dysfunctional cilia. Antibodies against CFAP298 are primarily used in research to investigate ciliary biology, protein localization, and disease mechanisms. They enable detection via techniques like immunofluorescence, Western blotting, and immunohistochemistry, often revealing reduced CFAP298 expression in PCD patient samples. Commercial CFAP298 antibodies are typically raised in rabbits or mice, with validation in model organisms like humans, mice, and zebrafish. Recent studies also explore CFAP298's potential role in sperm flagellar formation, highlighting its broader relevance in reproductive health. These tools remain vital for dissecting molecular pathways underlying ciliopathies and developing diagnostic biomarkers.