| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C1orf112 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C1orf112抗体的3篇示例参考文献(内容为虚构示例，实际文献需通过数据库验证)：
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1. **文献名称**: *"Characterization of a novel polyclonal antibody against human C1orf112 for cancer biomarker studies"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对C1orf112蛋白C端结构域的多克隆抗体，验证了其在免疫组化和Western blot中的特异性，发现C1orf112在结直肠癌组织中高表达，提示其作为潜在生物标志物的可能性。
2. **文献名称**: *"Subcellular localization and functional analysis of C1orf112 using monoclonal antibodies"*
**作者**: Zhang L, et al.
**摘要**: 通过单克隆抗体技术揭示C1orf112蛋白主要定位于细胞核及线粒体，并发现其通过与DNA修复蛋白相互作用参与基因组稳定性调控。
3. **文献名称**: *"C1orf112 antibody-based screening reveals its role in cellular stress response"*
**作者**: Lee S, et al.
**摘要**: 利用C1orf112特异性抗体进行功能研究，发现该蛋白在氧化应激条件下表达上调，敲低实验表明其可能通过调控自噬通路影响细胞存活。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词：C1orf112 antibody, protein characterization)，或参考抗体供应商(如Abcam、Santa Cruz)提供的引用文献。
The C1orf112 antibody is a research tool designed to target the protein encoded by the *C1orf112* gene (Chromosome 1 Open Reading Frame 112), a poorly characterized gene located on human chromosome 1. The gene's function remains largely unknown, though bioinformatic analyses suggest it may play roles in cellular processes such as DNA repair or cell cycle regulation. The encoded protein is predicted to contain coiled-coil domains, which are often involved in protein-protein interactions. C1orf112 antibodies are primarily used in experimental settings, including Western blotting, immunofluorescence, and immunohistochemistry, to detect protein expression levels, subcellular localization, and potential interaction partners.
Interest in C1orf112 has grown due to its reported associations with diseases such as cancer and neurodegenerative disorders, though mechanistic insights are limited. Some studies link its expression to tumor progression or chemoresistance, while others propose involvement in neuronal development. Commercial availability of C1orf112 antibodies is limited, and validation data (e.g., knockout controls) are critical to confirm specificity, as non-specific binding has been noted in some cases. Researchers often employ these antibodies to explore its tissue-specific expression patterns or to verify CRISPR/Cas9-mediated gene editing. Despite its enigmatic nature, C1orf112 represents a potential biomarker or therapeutic target, driving demand for reliable antibodies to advance functional studies. Further research is needed to clarify its biological significance and disease relevance.
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