| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RESA1; SELRC1; C1orf163 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COA7抗体的3篇参考文献示例(注：以下信息为基于领域知识的模拟内容，具体文献需通过学术数据库核实)：
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1. **文献名称**: *COA7 is essential for mitochondrial complex IV assembly and interacts with COX18 to stabilize the MITRAC complex*
**作者**: Müller JS, et al.
**摘要**: 本研究通过COA7特异性抗体进行免疫沉淀和Western blot分析，揭示了COA7在维持线粒体复合物IV(COX)组装中的关键作用，并发现其与COX18蛋白相互作用以稳定MITRAC复合物，从而影响线粒体呼吸功能。
2. **文献名称**: *A novel homozygous mutation in COA7 causes fatal infantile mitochondrial encephalopathy*
**作者**: Park S, et al.
**摘要**: 报道一例由COA7基因纯合突变导致的线粒体脑病病例，使用COA7抗体检测患者成纤维细胞中蛋白表达显著降低，证实突变导致COA7功能丧失，引发线粒体呼吸链缺陷和神经元退行性变。
3. **文献名称**: *Generation and validation of a polyclonal antibody targeting human COA7 for functional studies*
**作者**: Chen L, et al.
**摘要**: 描述了一种新型兔源多克隆抗体的开发，通过免疫印迹和免疫荧光验证其对人类COA7蛋白的特异性，并应用于细胞模型中研究COA7的亚线粒体定位及动态表达变化。
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**提示**：实际文献需通过PubMed、Google Scholar等平台以关键词“COA7 antibody”或“COA7 mitochondrial function”检索。建议结合研究背景筛选涉及抗体应用(如Western blot、免疫组化)的论文。
The COA7 (Cytochrome c Oxidase Assembly Factor 7) antibody is a research tool used to study the COA7 protein, which plays a critical role in mitochondrial function. COA7. also known as SELENOT or RESF1. is a mitochondrial matrix protein involved in the assembly and stability of Complex IV (cytochrome c oxidase) of the electron transport chain. It facilitates the incorporation of heme and copper cofactors into the enzyme, ensuring proper oxidative phosphorylation. Mutations in the COA7 gene are linked to mitochondrial disorders, such as Leigh syndrome and Charcot-Marie-Tooth disease, characterized by neurodegeneration and muscle weakness.
The COA7 antibody is typically utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect COA7 expression levels, subcellular localization, and tissue distribution. Studies employing this antibody have revealed reduced COA7 levels in disease models, highlighting its role in mitochondrial dysfunction and cellular stress responses. Researchers also investigate its interaction with other mitochondrial proteins to unravel molecular mechanisms underlying energy metabolism defects. Commercial COA7 antibodies are often raised in rabbits or mice, validated for specificity using knockout controls. Its application advances understanding of mitochondrial biology and potential therapeutic targets for metabolic and neurological diseases.
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