| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RDMS; SMDAX; LRRC76; YF5/A2; C21orf2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CFAP410 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CFAP410抗体的虚构参考文献示例(仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: *CFAP410 Antibody Localization in Human Ciliated Tissues*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用CFAP410特异性抗体，通过免疫荧光技术分析其在人类呼吸道纤毛细胞中的定位。结果显示CFAP410在基体周围富集，提示其参与纤毛组装调控，为纤毛功能障碍疾病机制提供新线索。
2. **文献名称**: *Role of CFAP410 in Sperm Flagella Development: Evidence from Knockout Mice*
**作者**: Tanaka K, et al.
**摘要**: 通过CFAP410抗体检测基因敲除小鼠精子超微结构，发现CFAP410缺失导致鞭毛结构异常和运动能力下降，证实其在哺乳动物精子发生中的关键作用。
3. **文献名称**: *CFAP410 Antibody Validation for Immunoblotting in Ciliopathy Models*
**作者**: Lee S, Patel R
**摘要**: 本研究系统验证了CFAP410抗体在斑马鱼和人类细胞系中的特异性，证实其在Western blot中可检测约50 kDa的条带，为纤毛病相关研究提供了可靠工具。
4. **文献名称**: *CFAP40/CFAP410 Double Mutation and Retinal Degeneration*
**作者**: Garcia-Gonzalez FR, et al.
**摘要**: 利用CFAP410抗体研究视网膜色素上皮细胞，发现其与CFAP40存在互作，双突变导致光感受器退化，提示二者协同维持纤毛稳定性。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索，建议结合关键词“CFAP410 antibody”或“CFAP40/CFAP410”查询近期研究。
CFAP410 (Cilia and Flagella Associated Protein 410), also known as C11orf30 or SDCCAG8. is a conserved ciliary protein critical for the assembly and stability of primary cilia and flagella. It localizes to the basal body and transition zone, playing a role in anchoring microtubules and regulating ciliary protein trafficking. Structurally, CFAP410 contains coiled-coil domains that facilitate protein interactions, particularly with components of the intraflagellar transport (IFT) system. Mutations in the CFAP410 gene are linked to ciliopathies, including Jeune asphyxiating thoracic dystrophy, short-rib polydactyly syndrome, and retinal degeneration, underscoring its importance in skeletal development, photoreceptor maintenance, and organ function.
Antibodies targeting CFAP410 are essential tools for studying ciliary biology and disease mechanisms. They are widely used in immunofluorescence, Western blotting, and immunohistochemistry to visualize CFAP410 expression, subcellular localization, and interaction networks. These antibodies aid in identifying pathogenic variants, assessing protein loss in knockout models, and exploring cilia-related signaling pathways (e.g., Hedgehog signaling). Commercially available CFAP410 antibodies are typically raised in rabbits or mice, validated for specificity using knockout controls or siRNA knockdown. Their applications extend to diagnostic research for ciliopathies and therapeutic development, offering insights into how CFAP410 dysfunction disrupts cellular homeostasis and contributes to multisystemic disorders.
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