Rabbit Polyclonal GATD3B Antibody

The GATD3B (Glycosyltransferase-like domain-containing protein 3B) antibody is a tool used to study the function and expression of the GATD3B protein, a mitochondrial enzyme implicated in protein quality control and post-translational modifications. GATD3B belongs to the glycosyltransferase-like family but lacks canonical glycosyltransferase activity. Instead, it is proposed to act as a chaperone or interactor in mitochondrial processes, particularly in the assembly or repair of mitochondrial membrane proteins. Its structure includes a conserved N-terminal domain and a C-terminal tetratricopeptide repeat (TPR) region, suggesting roles in protein-protein interactions. Dysregulation of GATD3B has been linked to mitochondrial disorders, metabolic syndromes, and certain cancers, making it a target for mechanistic and therapeutic research. The antibody, often raised in rabbits or mice, enables detection via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Validation typically involves knockout cell lines or tissues to confirm specificity. Researchers use this antibody to explore GATD3B’s involvement in mitochondrial dynamics, stress responses, and its potential as a biomarker. Commercial sources often provide it with detailed epitope information and application-specific optimization data.