| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | hCBR3; SDR21C2; HEL-S-25 |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CBR3抗体相关的研究文献示例(注：文献标题和作者为虚构示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*CBR3 Expression in Breast Cancer: A Novel Biomarker for Anthracycline Resistance*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化(使用CBR3抗体)发现CBR3在乳腺癌组织中的高表达与蒽环类化疗药物耐药性相关，提示其作为治疗靶点的潜力。
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2. **文献名称**：*Structural and Functional Analysis of Human Carbonyl Reductase 3 Using Monoclonal Antibodies*
**作者**：Wang L, et al.
**摘要**：开发了特异性CBR3单克隆抗体，通过Western blot和免疫荧光验证了其在细胞内的定位，揭示了CBR3的底物结合域结构特征。
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3. **文献名称**：*CBR3-Mediated Detoxification in Colorectal Cancer: Implications for Chemotherapy Response*
**作者**：Gupta R, et al.
**摘要**：利用CBR3抗体检测结直肠癌患者肿瘤组织中CBR3蛋白水平，发现其高表达与奥沙利铂代谢增强相关，可能影响化疗效果。
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如需真实文献，建议在PubMed或Google Scholar搜索关键词：
`"CBR3 antibody"` 或 `"Carbonyl Reductase 3" AND (antibody OR biomarker OR expression)`。
The CBR3 (carbonyl reductase 3) antibody is a tool used to study the CBR3 enzyme, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. CBR3 catalyzes NADPH-dependent reduction of carbonyl groups, playing a role in metabolizing endogenous and exogenous substrates, including prostaglandins, steroids, and xenobiotics. It is particularly notable for its involvement in the inactivation of anthracycline chemotherapeutics (e.g., doxorubicin), influencing drug efficacy and toxicity. Dysregulation of CBR3 has been linked to cancer progression, chemoresistance, and metabolic disorders, making it a target for therapeutic and diagnostic research.
The CBR3 antibody enables detection and quantification of CBR3 protein expression in tissues or cell lines, aiding investigations into its tissue-specific roles, enzymatic activity, and interactions. Researchers employ it in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore CBR3's localization and expression patterns in diseases such as breast cancer, hepatocellular carcinoma, and neurodegenerative conditions. Additionally, genetic polymorphisms in CBR3 affecting enzyme activity have prompted studies using the antibody to correlate protein levels with patient-specific drug responses or disease susceptibility. Its utility extends to preclinical models for evaluating CBR3's role in oxidative stress, detoxification pathways, and metabolic syndromes, highlighting its relevance in both basic research and translational medicine.
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