| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b |
| Entrez GeneID | 2944 |
| clone | 1H4A4 |
| WB Predicted band size | 26kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Purified recombinant fragment of human GSTM1 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
+ +
以下是关于CCT8L2抗体的模拟参考文献示例(注：CCT8L2研究较少，实际文献可能有限，建议通过PubMed或Google Scholar核实具体信息)：
1. **文献名称**: "CCT8L2 as a novel cancer biomarker: Expression analysis using a specific polyclonal antibody"
**作者**: Li X, Wang Y, Zhang H.
**摘要**: 研究开发了针对CCT8L2的多克隆抗体，通过免疫组化验证其在肺癌组织中的高表达，并提示其与肿瘤增殖相关。
2. **文献名称**: "Characterization of CCT8L2 antibody for detecting germ cell-specific chaperonin complexes"
**作者**: Tanaka K, et al.
**摘要**: 报道了一种特异性识别CCT8L2的单克隆抗体，用于研究其在哺乳动物生殖细胞中的表达模式及伴侣蛋白复合体功能。
3. **文献名称**: "CCT8L2 antibody validation in neurodegenerative disease models"
**作者**: Smith J, et al.
**摘要**: 验证了CCT8L2抗体在阿尔茨海默病脑组织样本中的特异性，发现其与tau蛋白异常聚集存在潜在关联。
4. **文献名称**: "Comparative study of CCT8 and CCT8L2 antibody specificity in primate evolution"
**作者**: Garcia-Ruiz I, et al.
**摘要**: 通过系统进化分析，利用抗体交叉实验揭示CCT8L2在灵长类中的独特表达谱及其基因复制后的功能分化。
**说明**：CCT8L2(Chaperonin Containing TCP1 Subunit 8 Like 2)属于伴侣蛋白家族，目前研究较少，上述文献为基于相关领域知识的模拟。实际应用中建议结合抗体货号(如Santa Cruz的sc-55572或Abcam的ab12345)在专业数据库中检索最新文献。
The CCT8L2 antibody targets the chaperonin-containing TCP-1 subunit 8-like 2 (CCT8L2) protein, a putative paralog of the CCT8 subunit within the chaperonin complex CCT/TRiC. This evolutionarily conserved complex assists in ATP-dependent folding of nascent polypeptides, including actin, tubulin, and cell cycle regulators. While CCT8 is a well-characterized subunit critical for substrate binding and structural integrity, CCT8L2 is considered a pseudogene or a low-expression variant in humans, with unclear functional divergence. Its gene locus on chromosome 11 and sequence homology to CCT8 suggest possible redundancy or regulatory roles.
Antibodies against CCT8L2 are primarily used in research to distinguish it from CCT8 and explore its expression patterns, particularly in cancers or neurological disorders where chaperonin dysregulation is implicated. However, due to high sequence similarity, cross-reactivity remains a challenge, requiring rigorous validation via knockout controls. Studies using CCT8L2 antibodies have detected weak or tissue-specific signals, hinting at restricted expression in certain cell types or developmental stages. Current efforts focus on clarifying whether CCT8L2 retains chaperone activity, acts as a dominant-negative regulator, or serves non-canonical roles in stress responses. Further characterization may uncover its relevance to proteostasis-related diseases.
×
