Rabbit Polyclonal ABCC6 Antibody

The ABCC6 antibody is a crucial tool for studying the ATP-binding cassette subfamily C member 6 (ABCC6), a transmembrane protein primarily expressed in the liver and kidneys. ABCC6 facilitates the transport of small molecules, though its exact physiological substrate remains unclear. Mutations in the ABCC6 gene cause pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by ectopic mineralization in tissues like skin, eyes, and blood vessels. ABCC6 dysfunction is also linked to cardiovascular calcification. Researchers use ABCC6 antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and quantification in cellular or tissue samples. These antibodies aid in exploring ABCC6's role in cellular detoxification, purinergic signaling, and mineral metabolism. Commercially available ABCC6 antibodies are typically developed in rabbits or mice, targeting specific epitopes. However, validation for specificity is essential due to potential cross-reactivity with other ABC transporters. Studies utilizing ABCC6 antibodies have advanced understanding of PXE pathogenesis and broader mechanisms of ectopic calcification, offering insights into therapeutic strategies. Ongoing research focuses on ABCC6's interaction with vitamin K metabolism and its potential diagnostic applications in metabolic disorders.