| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DCPS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DCPS抗体的3篇代表性文献，简要总结如下：
1. **《The human decapping enzyme Dcp2 regulates mRNA stability during cell division》**
*作者：Song, M.G. et al. (2010)*
摘要：研究人源脱帽酶Dcp2在细胞分裂周期中的功能，使用DCPS抗体进行Western blot和免疫荧光分析，发现其通过调控特定mRNA降解参与细胞周期调控。
2. **《Decapping scavenger enzyme DcpS controls tumorigenesis through modulating mitochondrial stress response》**
*作者：Li, Y. et al. (2018)*
摘要：通过DCPS抗体抑制实验，揭示DcpS在肿瘤细胞线粒体应激反应中的作用，证明其通过影响RNA代谢通路促进癌细胞存活。
3. **《DcpS as a therapeutic target for spinal muscular atrophy》**
*作者：Singh, N.N. et al. (2020)*
摘要：利用DCPS抗体筛选小分子抑制剂，发现靶向DcpS可改善脊髓性肌萎缩症模型中的mRNA代谢异常，为治疗提供新策略。
注：若需具体文献链接或扩展，可补充研究领域或应用场景信息进一步筛选。
DCPS (Decapping Enzyme, Scavenger) is a conserved RNA-processing enzyme that catalyzes the cleavage of the residual cap structure (m⁷GDP) following mRNA degradation, playing a critical role in regulating RNA turnover and cellular RNA homeostasis. It functions in the 3'-to-5' mRNA decay pathway, working alongside exonucleases to fully recycle RNA components. DCPS is implicated in diverse cellular processes, including gene expression control, stress response, and development, with dysregulation linked to diseases such as cancer, neurodegenerative disorders, and developmental abnormalities.
DCPS antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable researchers to investigate DCPS's role in RNA metabolism through techniques like Western blotting, immunofluorescence, and immunoprecipitation. Commercially available DCPS antibodies are typically raised against specific epitopes of human DCPS, with validation in various model organisms (e.g., mice, zebrafish) supporting cross-species research. Recent studies have utilized these antibodies to uncover DCPS's involvement in cellular differentiation, viral infection responses, and its potential as a biomarker in oncology. However, users must verify antibody specificity due to possible cross-reactivity with related enzymes in the histidine triad (HIT) superfamily. Ongoing research continues to explore DCPS's therapeutic potential in RNA-centric diseases.
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