| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DEM1; Exo V; hExo5; C1orf176 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human EXO5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下提供的参考文献为示例性内容，并非真实存在的文献，仅供格式参考：
1. **文献名称**: "EXO5 Antibody as a Novel Biomarker in Colorectal Cancer Detection"
**作者**: Zhang, L., et al.
**摘要**: 本研究探讨了EXO5抗体在结直肠癌患者血清中的表达水平，发现其与肿瘤进展呈正相关，可能作为早期诊断的生物标志物。通过ELISA和免疫组化验证了EXO5抗体的特异性。
2. **文献名称**: "Characterization of EXO5-Specific Monoclonal Antibodies for DNA Repair Studies"
**作者**: Smith, J.R., & Kumar, P.
**摘要**: 研究团队开发了一种高特异性的EXO5单克隆抗体，用于检测DNA损伤修复过程中外切酶EXO5的表达动态，证实其在同源重组修复中的关键作用。
3. **文献名称**: "EXO5 Autoantibodies in Neurodegenerative Disorders: A Case-Control Study"
**作者**: Gomez, M., et al.
**摘要**: 分析阿尔茨海默病和帕金森病患者脑脊液样本，发现EXO5自身抗体的异常升高可能与神经元DNA损伤积累有关，提示其在神经退行性疾病中的潜在病理机制。
4. **文献名称**: "Development of a Commercial EXO5 Antibody for Exosome Surface Protein Detection"
**作者**: Chen, X., et al.
**摘要**: 该文献报道了一种针对外泌体表面蛋白EXO5的兔源多克隆抗体的制备与验证，证明其在流式细胞术和超分辨显微成像中的应用潜力。
---
如需真实文献，建议通过PubMed、Google Scholar等平台，以“EXO5 antibody”、“Exonuclease 5 antibody”等关键词检索，并筛选近年的研究。注意确认目标蛋白的全称及研究背景的匹配性。
EXO5 antibody targets the EXO5 protein, a key enzyme in the DNA repair pathway known as nucleotide excision repair (NER). EXO5. or exonuclease 5. is a structure-specific endonuclease conserved across eukaryotes, including humans. It plays a critical role in processing DNA intermediates during NER, particularly in excising damaged DNA strands caused by UV-induced lesions or chemical adducts. Studies suggest EXO5 interacts with other NER components, such as XPG and XPF-ERCC1. to ensure precise cleavage of DNA lesions, maintaining genomic stability. Its dual nuclease activity—acting on both 3' and 5' overhangs—distinguishes it from other repair enzymes.
Research on EXO5 antibodies has advanced understanding of its functional mechanisms and cellular localization. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study EXO5 expression, regulation, and involvement in DNA damage response. Dysregulation of EXO5 has been linked to genomic instability and diseases like xeroderma pigmentosum (XP), a condition tied to defective NER. Recent work also explores its potential role in replication stress and cancer biology. By enabling precise detection of EXO5. these antibodies support investigations into DNA repair pathways, offering insights for therapeutic strategies targeting repair-deficient cancers or genetic disorders.
×
