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Rabbit Polyclonal EIF2AK1 Antibody

  • 中文名： EIF2AK1抗体
  • 别    名： HCR; HRI
货号: IPDX09934
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHCR; HRI
WB Predicted band size71 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human EIF2AK1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于 **EIF2AK1抗体** 的3篇参考文献示例(文献名称、作者及摘要概括)：

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1. **文献名称**: *"Characterization of HRI/eIF2α Kinase in Hemin-regulated Erythropoiesis"*

**作者**: Chen JJ, et al.

**摘要**: 研究利用特异性EIF2AK1抗体，揭示了该激酶在血红素缺乏时通过磷酸化eIF2α调控红细胞分化的机制，并验证了抗体在检测内源性HRI蛋白表达中的应用。

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2. **文献名称**: *"EIF2AK1 Promotes Tumor Cell Survival under Oxidative Stress via ATF4 Pathway"*

**作者**: Zhang Y, et al.

**摘要**: 通过EIF2AK1抗体进行免疫印迹和免疫组化实验，发现EIF2AK1在肺癌细胞中高表达，并通过激活ATF4依赖的应激反应通路促进癌细胞在氧化应激环境下的存活。

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3. **文献名称**: *"Development of a Monoclonal Antibody for EIF2AK1 and Its Application in Neurodegenerative Disease Models"*

**作者**: Smith RD, et al.

**摘要**: 报道了一种高特异性抗EIF2AK1单克隆抗体的开发，该抗体成功用于阿尔茨海默病模型小鼠脑组织中EIF2AK1蛋白的定位及表达水平分析，提示其与神经退行性病变相关。

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**备注**：以上文献为示例，实际引用需根据具体研究内容选择正式发表的论文。建议通过PubMed或Google Scholar搜索关键词(如“EIF2AK1 antibody”、“HRI kinase detection”)获取最新文献。

背景信息

EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1), also known as heme-regulated inhibitor (HRI), is a stress-responsive serine/threonine kinase belonging to the EIF2AK family. It plays a critical role in regulating protein synthesis under cellular stress by phosphorylating the alpha subunit of eukaryotic initiation factor 2 (eIF2α), which attenuates global translation while promoting selective gene expression. EIF2AK1 is uniquely activated by heme deficiency, oxidative stress, and proteotoxic insults, making it a key mediator in erythroid differentiation, iron metabolism, and mitochondrial stress responses. Structurally, it contains a kinase domain, a heme-binding regulatory region, and motifs for dimerization and stress sensing. Dysregulation of EIF2AK1 has been implicated in erythropoietic disorders, neurodegenerative diseases, and cancer progression. Antibodies targeting EIF2AK1 are essential tools for studying its expression, activation status, and interactions in various pathological and physiological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore its role in stress adaptation pathways and therapeutic targeting strategies. Research on EIF2AK1 continues to uncover its nuanced involvement in cellular homeostasis and disease mechanisms.

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