Rabbit Polyclonal EIF2AK1 Antibody

EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1), also known as heme-regulated inhibitor (HRI), is a stress-responsive serine/threonine kinase belonging to the EIF2AK family. It plays a critical role in regulating protein synthesis under cellular stress by phosphorylating the alpha subunit of eukaryotic initiation factor 2 (eIF2α), which attenuates global translation while promoting selective gene expression. EIF2AK1 is uniquely activated by heme deficiency, oxidative stress, and proteotoxic insults, making it a key mediator in erythroid differentiation, iron metabolism, and mitochondrial stress responses. Structurally, it contains a kinase domain, a heme-binding regulatory region, and motifs for dimerization and stress sensing. Dysregulation of EIF2AK1 has been implicated in erythropoietic disorders, neurodegenerative diseases, and cancer progression. Antibodies targeting EIF2AK1 are essential tools for studying its expression, activation status, and interactions in various pathological and physiological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore its role in stress adaptation pathways and therapeutic targeting strategies. Research on EIF2AK1 continues to uncover its nuanced involvement in cellular homeostasis and disease mechanisms.