| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SWAN; SCZD19; HRIHFB2091 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RBM12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RBM12抗体的模拟参考文献示例(内容为假设性概括，需根据实际文献调整)：
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1. **文献名称**: *RBM12 modulates tau aggregation in Alzheimer’s disease*
**作者**: Smith J, et al. (2018)
**摘要**: 研究利用RBM12特异性抗体检测其在阿尔茨海默病患者脑组织中的表达，发现RBM12与tau蛋白异常聚集相关，可能通过RNA剪接调控疾病进程。
2. **文献名称**: *Development and validation of a rabbit monoclonal antibody against human RBM12*
**作者**: Zhang L, et al. (2020)
**摘要**: 描述了兔源单克隆RBM12抗体的制备过程，通过免疫印迹(WB)和免疫组化(IHC)验证其特异性，证明其在癌症组织中的检测适用性。
3. **文献名称**: *RBM12 promotes hepatocellular carcinoma metastasis via alternative splicing regulation*
**作者**: Chen X, et al. (2022)
**摘要**: 使用RBM12抗体分析肝癌细胞系，发现其高表达通过调控靶基因剪接促进肿瘤侵袭，抗体在预后标志物研究中显示潜在价值。
4. **文献名称**: *RBM12 interacts with RNA-binding proteins in neuronal development*
**作者**: Johnson R, et al. (2019)
**摘要**: 通过免疫共沉淀(Co-IP)结合RBM12抗体，揭示其与多种RNA结合蛋白的相互作用网络，提示其在神经发育中的调控功能。
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**注意**：以上文献信息为示例性质，实际引用需以真实出版物为准。建议通过PubMed或Google Scholar以“RBM12 antibody”为关键词检索最新文献。
The RBM12 antibody is a tool used to detect the RNA-binding motif protein 12 (RBM12), a protein encoded by the *RBM12* gene in humans. RBM12 belongs to the RNA-binding protein family, characterized by the presence of RNA recognition motifs (RRMs) that facilitate interactions with RNA molecules. This protein is implicated in post-transcriptional regulation, including mRNA processing, splicing, and translation. Studies suggest its involvement in cellular processes such as cell cycle control, apoptosis, and stress responses, with emerging roles in cancer biology and neurological disorders. Dysregulation of RBM12 has been linked to hepatocellular carcinoma, breast cancer, and neurodegenerative conditions, highlighting its potential as a biomarker or therapeutic target.
RBM12 antibodies are typically polyclonal or monoclonal antibodies generated by immunizing hosts (e.g., rabbits or mice) with purified RBM12 protein fragments or synthetic peptides. These antibodies are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Specificity is confirmed using knockout cell lines or siRNA-mediated knockdown controls. Commercial RBM12 antibodies often target epitopes within conserved regions, such as the N-terminal or RRM domains. Researchers use these antibodies to explore RBM12's molecular interactions, subcellular localization (primarily nuclear), and regulatory mechanisms in disease models. Due to its association with splicing machinery and signaling pathways (e.g., Wnt/β-catenin), RBM12 remains a focus in studies of gene expression networks and RNA biology.
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