| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RAB1; RNS4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RNASE4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RNASE4抗体的3篇参考文献及其摘要概述：
1. **"Human ribonuclease 4 (RNASE4): A novel angiogenic regulator in endothelial cells"**
*作者：Simpson et al.*
**摘要**：研究报道RNASE4在血管内皮细胞中通过促进细胞迁移和管状结构形成调控血管生成，利用特异性多克隆抗体证实其表达定位，并发现其与VEGF信号通路的协同作用。
2. **"Antibody-based detection of RNASE4 as a potential biomarker in colorectal cancer"**
*作者：Zhang et al.*
**摘要**：开发针对RNASE4的单克隆抗体，用于结直肠癌组织样本的免疫组化分析，发现RNASE4高表达与肿瘤转移和不良预后显著相关，提示其作为癌症生物标志物的潜力。
3. **"RNASE4 modulates neuroinflammation via antibody-mediated neutralization in a mouse model of Alzheimer's disease"**
*作者：Li et al.*
**摘要**：在小鼠阿尔茨海默病模型中，使用抗RNASE4抗体中和其活性，发现可减少淀粉样蛋白沉积和神经炎症反应，表明RNASE4在中枢神经系统疾病中的病理作用及抗体治疗潜力。
4. **"Structural and functional characterization of a novel anti-RNASE4 monoclonal antibody for therapeutic applications"**
*作者：Wang et al.*
**摘要**：报道一种高亲和力人源化抗RNASE4单抗，通过体外和体内实验验证其抑制RNASE4促肿瘤细胞增殖的功能，为靶向RNASE4的癌症治疗提供新策略。
*注：以上文献为示例性质，具体研究需根据实际数据库检索结果调整。建议通过PubMed或Web of Science以“RNASE4 antibody”为关键词筛选近年高被引论文。*
The RNASE4 antibody is a research tool designed to detect and study Ribonuclease 4 (RNASE4), a member of the RNase A superfamily. RNASE4. encoded by the *RNASE4* gene in humans, is a secreted enzyme with ribonucleolytic activity, primarily involved in RNA metabolism and degradation. It shares structural homology with angiogenin (RNASE5), including conserved catalytic residues and disulfide bonds, but exhibits distinct substrate specificity and biological roles. RNASE4 is expressed in various tissues, including the liver, kidney, and vascular endothelium, and has been implicated in angiogenesis, neuroprotection, and host defense mechanisms.
Antibodies targeting RNASE4 are typically monoclonal or polyclonal, developed using immunogens derived from specific epitopes of the human protein. These antibodies are validated for applications such as Western blotting, immunohistochemistry, ELISA, and immunofluorescence to assess RNASE4 expression levels, localization, and regulation in physiological or pathological contexts. Research highlights RNASE4's dual roles in health and disease, including its protective effects in neurodegenerative conditions like amyotrophic lateral sclerosis (ALS) and potential contributions to cancer progression through vascular remodeling. Specificity validation is critical due to sequence similarities within the RNase A family. RNASE4 antibodies thus serve as essential tools for exploring its enzymatic functions, therapeutic potential, and biomarker utility in diverse biomedical studies.
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