| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | G1L |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RNF24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与RNF24抗体相关的虚拟参考文献示例(注：实际文献需通过学术数据库查询)：
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1. **文献名称**：*Characterization of RNF24 Antibody Specificity in Ubiquitination Pathways*
**作者**：Li, X. et al.
**摘要**：本研究验证了兔源多克隆抗RNF24抗体在HEK293细胞中的特异性，通过siRNA敲低和Western blot确认其识别内源性RNF24蛋白的能力，并发现RNF24参与调控膜蛋白的泛素化降解过程。
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2. **文献名称**：*RNF24 Expression in Male Reproductive System: An Immunohistochemical Study*
**作者**：Gupta, R. & Yamamoto, T.
**摘要**：利用小鼠模型和商业化RNF24单克隆抗体，揭示RNF24在睾丸生精细胞中的高表达，提示其可能在精子发生中通过泛素-蛋白酶体系统调控蛋白质稳态。
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3. **文献名称**：*RNF24 as a Novel Biomarker in Colorectal Cancer: Antibody Validation and Clinical Correlation*
**作者**：Chen, L. et al.
**摘要**：通过免疫组化验证抗RNF24抗体在结直肠癌组织中的可靠性，发现RNF24在癌组织中的异常高表达与患者预后不良显著相关，提示其可能作为潜在治疗靶点。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词“RNF24 antibody”、“RNF24 ubiquitin”或结合具体研究领域(如癌症、生殖生物学)。部分研究可能侧重于抗体应用而非专门描述抗体特性，需结合上下文筛选。
The RNF24 (Ring Finger Protein 24) antibody is a research tool designed to detect and study the RNF24 protein, a member of the E3 ubiquitin ligase family. RNF24 contains a conserved RING domain that facilitates its role in ubiquitination, a post-translational modification process critical for protein degradation, signal transduction, and cellular homeostasis. This protein is implicated in diverse biological processes, including endoplasmic reticulum (ER)-Golgi trafficking, vesicle transport, and stress response pathways. Dysregulation of RNF24 has been linked to pathologies such as cancer, neurodegenerative disorders, and cardiovascular diseases, highlighting its potential as a therapeutic target.
RNF24 antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate its expression, localization, and interactions in various tissues or cell lines. Researchers rely on these antibodies to explore RNF24's role in cellular mechanisms, such as modulating membrane protein stability or regulating autophagy. Specificity and validation of RNF24 antibodies are crucial, as cross-reactivity with homologous proteins (e.g., RNF19A/B) may occur due to structural similarities within the RING domain family. Recent studies also suggest RNF24's involvement in immune responses and viral infection pathways, expanding its relevance in both basic and translational research. Continued development of high-affinity RNF24 antibodies remains essential for unraveling its multifaceted functions in health and disease.
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