Rabbit Polyclonal MGST3 Antibody

The MGST3 (Microsomal Glutathione S-Transferase 3) antibody is a tool used to study the MGST3 protein, a member of the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family. MGST3 is a membrane-bound enzyme localized primarily in the endoplasmic reticulum and mitochondria. It plays a critical role in cellular detoxification by catalyzing the conjugation of glutathione to electrophilic substrates, thereby neutralizing reactive oxygen species (ROS) and toxic compounds. This enzyme is also involved in regulating inflammatory responses and maintaining redox homeostasis. Research on MGST3 has linked it to processes such as oxidative stress mitigation, drug metabolism, and apoptosis modulation. Antibodies targeting MGST3 enable the detection and quantification of its expression in various tissues and cell types using techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing MGST3 antibodies have explored its upregulated expression in certain cancers, suggesting potential roles in tumor progression and chemoresistance. Additionally, its involvement in neurodegenerative and cardiovascular diseases highlights broader therapeutic implications. The availability of specific MGST3 antibodies supports ongoing investigations into its biochemical mechanisms, substrate specificity, and interactions with other detoxification pathways.